Cathepsin G substrate, Colorimetric substrate for cathepsin G (ab145602)

Overview

  • Product name

    Cathepsin G substrate, Colorimetric substrate for cathepsin G
  • Description

    Colorimetric substrate for cathepsin G
  • Biological description

    Colorimetric substrate for cathepsin G. May be measured for absorbance at 405 nm similar to methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide.

  • Purity

    > 95%
  • CAS Number

    70967-91-8
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    622.69
  • Molecular formula

    C27H38N6O9S
  • Sequence

    AAPM (Modifications: N-terminal methoxysuccinyl; C-terminal pNA)
  • PubChem identifier

    4549509
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CCSC)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCC(=O)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Legowska A  et al. Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors. Bioorg Med Chem 17:3302-7 (2009). Read more (PubMed: 19362846) »
  • Lesner A  et al. Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods. Anal Biochem 375:306-12 (2008). Read more (PubMed: 18261971) »
  • Nakajima K  et al. Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site. J Biol Chem 254:4027-32 (1979). Read more (PubMed: 312290) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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