Anti-Cathepsin K antibody (ab19027)

Rabbit polyclonal Cathepsin K antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human, Zebrafish. Cited in 55 publication(s). Independently reviewed in 17 review(s).

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ab19027 has been referenced in 57 publications.

  • Chen CH  et al. A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis. J Clin Med 8:N/A (2019). PubMed: 30717291
  • Liu W  et al. Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration. ACS Appl Mater Interfaces 11:9557-9572 (2019). PubMed: 30720276
  • Gao Y & Ge W The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis. Cell Death Dis 9:33 (2018). PubMed: 29348610
  • Breznik B  et al. Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches. J Mol Histol 49:481-497 (2018). PubMed: 30046941
  • Chen CH  et al. An osteopenic/osteoporotic phenotype delays alveolar bone repair. Bone 112:212-219 (2018). PubMed: 29704698
  • Tokarz D  et al. Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia. J Bone Miner Res 33:499-509 (2018). PubMed: 29083055
  • Alemi AS  et al. Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling. Bone Rep 9:145-153 (2018). PubMed: 30306100
  • Liu H  et al. Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/ß-catenin and osteoprotegerin/receptor activator for nuclear factor-?B ligand/cathepsin K signaling in ovariectomized rats. Phytother Res 32:2487-2500 (2018). PubMed: 30306652
  • Liu C  et al. Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-?B Signaling in Diabetic Rats. Front Pharmacol 9:1239 (2018). PubMed: 30459613
  • Cai M  et al. A bone-resorption surface-targeting nanoparticle to deliver anti-miR214 for osteoporosis therapy. Int J Nanomedicine 12:7469-7482 (2017). PubMed: 29075114
  • Longhofer LK  et al. Specific material effects of wear-particle-induced inflammation and osteolysis at the bone-implant interface: A rat model. J Orthop Translat 8:5-11 (2017). PubMed: 30035088
  • Dole NS  et al. Osteocyte-Intrinsic TGF-ß Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling. Cell Rep 21:2585-2596 (2017). IHC-P ; Mouse . PubMed: 29186693
  • Nagy E  et al. Interferon-? Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Am J Pathol 187:1413-1425 (2017). IHC-Fr ; Human . PubMed: 28431214
  • Wang H  et al. Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Nat Commun 8:15045 (2017). IF . PubMed: 28429794
  • Lin YY  et al. Excavatolide B Attenuates Rheumatoid Arthritis through the Inhibition of Osteoclastogenesis. Mar Drugs 15:N/A (2017). IHC-P ; Rat . PubMed: 28067799
  • Jiang T  et al. Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse. PLoS One 12:e0169857 (2017). PubMed: 28095448
  • Mi B  et al. Strontium-loaded titania nanotube arrays repress osteoclast differentiation through multiple signalling pathways: In vitro and in vivo studies. Sci Rep 7:2328 (2017). PubMed: 28539667
  • Knöpfel T  et al. The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction. Sci Rep 7:11018 (2017). IHC-P ; Mouse . PubMed: 28887454
  • Lee JW  et al. The HIV co-receptor CCR5 regulates osteoclast function. Nat Commun 8:2226 (2017). PubMed: 29263385
  • Gonçalves AF  et al. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat Commun 8:1466 (2017). PubMed: 29133867
  • Ren H  et al. Promotion effect of extracts from plastrum testudinis on alendronate against glucocorticoid-induced osteoporosis in rat spine. Sci Rep 7:10617 (2017). PubMed: 28878388
  • Haraguchi R  et al. sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss. Sci Rep 6:25198 (2016). IHC . PubMed: 27117872
  • Li D  et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun 7:10872 (2016). IHC . PubMed: 26947250
  • Manku G & Culty M Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells. Int J Mol Sci 17:N/A (2016). PubMed: 27608010
  • Cabahug-Zuckerman P  et al. Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs. J Bone Miner Res 31:1356-65 (2016). PubMed: 26852281
  • Akiba Y  et al. The inhibitors of cyclin-dependent kinases and GSK-3ß enhance osteoclastogenesis. Biochem Biophys Rep 5:253-258 (2016). PubMed: 28955831
  • Hira VV  et al. CD133+ and Nestin+ Glioma Stem-Like Cells Reside Around CD31+ Arterioles in Niches that Express SDF-1a, CXCR4, Osteopontin and Cathepsin K. J Histochem Cytochem 63:481-93 (2015). PubMed: 25809793
  • Katsuyama E  et al. Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells. J Biol Chem 290:716-26 (2015). IHC-P ; Mouse . PubMed: 25404736
  • Ju X  et al. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. J Virol 89:10347-58 (2015). PubMed: 26246576
  • Fowler TW  et al. Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci 128:683-94 (2015). PubMed: 25609708
  • Marthandan S  et al. Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts. Biomed Res Int 2015:731938 (2015). WB . PubMed: 26339636
  • Wang D  et al. 1a,25-Dihydroxyvitamin D3 inhibits the differentiation and bone resorption by osteoclasts generated from Wistar rat bone marrow-derived macrophages. Exp Ther Med 10:1039-1044 (2015). PubMed: 26622436
  • Chen AC  et al. Physical and functional interaction between the a- and ?-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol 211:1157-76 (2015). PubMed: 26694839
  • Liang N  et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med 211:2249-63 (2014). IHC-P ; Mouse . PubMed: 25288394
  • James AW  et al. Lentiviral delivery of PPAR? shRNA alters the balance of osteogenesis and adipogenesis, improving bone microarchitecture. Tissue Eng Part A 20:2699-710 (2014). PubMed: 24785569
  • Murphy KE  et al. Reduced glucocerebrosidase is associated with increased a-synuclein in sporadic Parkinson's disease. Brain 137:834-48 (2014). PubMed: 24477431
  • Huyard F  et al. Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk. PLoS One 9:e92287 (2014). IF ; Rat . PubMed: 24743169
  • Maekawa T  et al. Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis. J Immunol 192:6020-7 (2014). PubMed: 24808362
  • Xu Q  et al. Ultraviolet A-induced cathepsin K expression is mediated via MAPK/AP-1 pathway in human dermal fibroblasts. PLoS One 9:e102732 (2014). WB ; Human . PubMed: 25048708
  • Boeyens JC  et al. Effects of ?3- and ?6-polyunsaturated fatty acids on RANKL-induced osteoclast differentiation of RAW264.7 cells: a comparative in vitro study. Nutrients 6:2584-601 (2014). WB . PubMed: 25010555
  • Hassanpour S  et al. The actin binding protein adseverin regulates osteoclastogenesis. PLoS One 9:e109078 (2014). WB ; Mouse . PubMed: 25275604
  • Verbovšek U  et al. Expression analysis of all protease genes reveals cathepsin K to be overexpressed in glioblastoma. PLoS One 9:e111819 (2014). IHC-Fr, WB ; Human . PubMed: 25356585
  • Charli-Joseph Y  et al. Primary cutaneous perivascular epithelioid cell tumor: a clinicopathological and molecular reappraisal. J Am Acad Dermatol 71:1127-36 (2014). PubMed: 25267378
  • Grevers LC  et al. Immune complex-induced inhibition of osteoclastogenesis is mediated via activating but not inhibitory Fc? receptors on myeloid precursor cells. Ann Rheum Dis 72:278-85 (2013). Mouse . PubMed: 22918932
  • Lin YY  et al. A soft coral-derived compound, 11-epi-sinulariolide acetate suppresses inflammatory response and bone destruction in adjuvant-induced arthritis. PLoS One 8:e62926 (2013). IHC-P ; Rat . PubMed: 23675440
  • Rementer CW  et al. An inducible, ligand-independent receptor activator of NF-?B gene to control osteoclast differentiation from monocytic precursors. PLoS One 8:e84465 (2013). PubMed: 24386387
  • Muruganandan S  et al. Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Stem Cells 31:2172-82 (2013). PubMed: 23766088
  • Petrey AC  et al. Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II. Dis Model Mech 5:177-90 (2012). IHC-P ; Zebrafish . PubMed: 22046029
  • Schmit JM  et al. Cathepsin K expression and activity in canine osteosarcoma. J Vet Intern Med 26:126-34 (2012). WB, ICC/IF ; Human, Dog . PubMed: 22171552
  • Qing H  et al. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res 27:1018-29 (2012). PubMed: 22308018
  • Blumer MJ  et al. Role of tartrate-resistant acid phosphatase (TRAP) in long bone development. Mech Dev 129:162-76 (2012). IHC . PubMed: 22579636
  • Marijnissen RJ  et al. Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. Arthritis Rheum 63:2939-48 (2011). PubMed: 21618207
  • Stempel J  et al. Development of articular cartilage and the metaphyseal growth plate: the localization of TRAP cells, VEGF, and endostatin. J Anat 218:608-18 (2011). PubMed: 21457260
  • Voigt M  et al. Fibroblast growth factor (FGF)-23 and fetuin-A in calcified carotid atheroma. Histopathology 56:775-88 (2010). IHC-P ; Human . PubMed: 20546343
  • Dominici M  et al. Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation. Blood 114:2333-43 (2009). IHC-P ; Mouse . PubMed: 19433859
  • Quintanilla-Dieck MJ  et al. Expression and regulation of cathepsin K in skin fibroblasts. Exp Dermatol 18:596-602 (2009). WB ; Human . PubMed: 19469903
  • Quintanilla-Dieck MJ  et al. Cathepsin K in melanoma invasion. J Invest Dermatol 128:2281-8 (2008). WB ; Human . PubMed: 18368130

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