Anti-Cathepsin K antibody (ab19027)
Key features and details
- Rabbit polyclonal to Cathepsin K
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
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Overview
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Product name
Anti-Cathepsin K antibody
See all Cathepsin K primary antibodies -
Description
Rabbit polyclonal to Cathepsin K -
Host species
Rabbit -
Specificity
ab19027 recognises cathepsin K. -
Tested Applications & Species
See all applications and species dataApplication Species WB Rat
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Immunogen
Synthetic peptide, corresponding to a region within amino acids 300-329 of Rat Cathepsin K which includes residue 321. (Peptide available as ab41720.)
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Positive control
- WB: Rat kidney tissue lysate
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.03% Proclin 300
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.015% EDTA -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Assay kits
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab19027 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| WB |
Rat
|
| Application | Abreviews | Notes |
|---|---|---|
| WB | (6) |
Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 37 kDa.
|
| Notes |
|---|
|
WB
Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 37 kDa. |
Target
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Function
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. -
Tissue specificity
Predominantly expressed in osteclasts (bones). -
Involvement in disease
Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. -
Sequence similarities
Belongs to the peptidase C1 family. -
Cellular localization
Lysosome. - Information by UniProt
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Database links
- Entrez Gene: 29175 Rat
- SwissProt: O35186 Rat
- Unigene: 5598 Rat
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Alternative names
- Cathepsin K antibody
- Cathepsin O antibody
- Cathepsin O1 antibody
see all
Images
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Western blot - Anti-Cathepsin K antibody (ab19027)Anti-Cathepsin K antibody (ab19027) + Rat kidney tissue lysate
Predicted band size: 37 kDa
Protocols
References (77)
ab19027 has been referenced in 77 publications.
- Pan J et al. Interspecies comparison of alveolar bone biology: Tooth extraction socket healing in mini pigs and mice. J Periodontol N/A:N/A (2020). PubMed: 32347546
- Turkkahraman H et al. Root resorption and ensuing cementum repair by Wnt/ß-catenin dependent mechanism. Am J Orthod Dentofacial Orthop N/A:N/A (2020). PubMed: 32381434
- Sun Z et al. Macrophage galectin-3 enhances intimal translocation of vascular calcification in diabetes mellitus. Am J Physiol Heart Circ Physiol 318:H1068-H1079 (2020). PubMed: 32216615
- Chen CH et al. A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis. J Clin Med 8:N/A (2019). PubMed: 30717291
- Liu W et al. Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration. ACS Appl Mater Interfaces 11:9557-9572 (2019). PubMed: 30720276
Customer reviews and Q&As
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