Anti-Cathepsin K antibody [C1] (ab239506)
Key features and details
- Mouse monoclonal [C1] to Cathepsin K
- Suitable for: WB
- Reacts with: Rat, Human, Pig
- Isotype: IgG2b
Overview
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Product name
Anti-Cathepsin K antibody [C1]
See all Cathepsin K primary antibodies -
Description
Mouse monoclonal [C1] to Cathepsin K -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat, Human, Pig
Predicted to work with: Rabbit, Cow, Dog, Cynomolgus monkey, Rhesus monkey -
Immunogen
Recombinant full length protein (His-tag) corresponding to Human Cathepsin K aa 100 to the C-terminus. N-terminal His-tag (Expressed in E.coli).
Database link: P43235 -
Positive control
- WB: Human lung lysate; Pig uterus and heart lysates; Rat skeletal muscle lysate; Recombinant human Cathepsin K protein.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS -
Concentration information loading...
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Purity
Protein A/G purified -
Purification notes
Purified from TCS. -
Clonality
Monoclonal -
Clone number
C1 -
Isotype
IgG2b -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab239506 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use a concentration of 0.5 - 5 µg/ml. Predicted molecular weight: 37 kDa.
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Notes |
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WB
Use a concentration of 0.5 - 5 µg/ml. Predicted molecular weight: 37 kDa. |
Target
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Function
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. -
Tissue specificity
Predominantly expressed in osteclasts (bones). -
Involvement in disease
Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. -
Sequence similarities
Belongs to the peptidase C1 family. -
Cellular localization
Lysosome. - Information by UniProt
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Database links
- Entrez Gene: 513038 Cow
- Entrez Gene: 102120416 Cynomolgus monkey
- Entrez Gene: 1513 Human
- Entrez Gene: 397569 Pig
- Entrez Gene: 100009334 Rabbit
- Entrez Gene: 29175 Rat
- Entrez Gene: 574112 Rhesus monkey
- Omim: 601105 Human
see all -
Alternative names
- Cathepsin K antibody
- Cathepsin O antibody
- Cathepsin O1 antibody
see all
Images
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Anti-Cathepsin K antibody [C1] (ab239506) at 3 µg/ml + Pig uterus lysate
Predicted band size: 37 kDa -
Anti-Cathepsin K antibody [C1] (ab239506) at 3 µg/ml + Pig heart lysate
Predicted band size: 37 kDa -
Anti-Cathepsin K antibody [C1] (ab239506) at 3 µg/ml + Rat skeletal muscle lysate
Predicted band size: 37 kDa -
Anti-Cathepsin K antibody [C1] (ab239506) at 2 µg/ml + Recombinant human Cathepsin K protein
Secondary
HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution
Predicted band size: 37 kDa -
Anti-Cathepsin K antibody [C1] (ab239506) at 2 µg/ml + Human lung lysate
Secondary
HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution
Predicted band size: 37 kDa
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab239506 has not yet been referenced specifically in any publications.