Key features and details
- Rabbit polyclonal to Cathepsin K - Catalytic domain
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Cathepsin K antibody - Catalytic domain
See all Cathepsin K primary antibodies
DescriptionRabbit polyclonal to Cathepsin K - Catalytic domain
Specificityab49893 recognizes all three forms of Cathepsin K (but does not see the 258 amino acid form as well as the other two forms, due to a partial deletion of the sequence).
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide based on the catalytic domain of human Cathepsin K.
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 50% Glycerol, 2.9% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab49893 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent dilution. Predicted molecular weight: 37 kDa. A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates.|
FunctionClosely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Tissue specificityPredominantly expressed in osteclasts (bones).
Involvement in diseaseDefects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.
Sequence similaritiesBelongs to the peptidase C1 family.
- Information by UniProt
- Cathepsin K antibody
- Cathepsin O antibody
- Cathepsin O1 antibody
All lanes : Anti-Cathepsin K antibody - Catalytic domain (ab49893) at 1/1000 dilution
Lane 1 : r-Human Cathepsin K at 0.04 µg
Lane 2 : r-Human Cathepsin K at 0.02 µg
Lane 3 : r-Human Cathepsin K at 0.01 µg
Lane 4 : r-Human Cathepsin K at 0.004 µg
Lane 5 : r-Human Cathepsin K at 0.002 µg
Predicted band size: 37 kDa
ab49893 has been referenced in 1 publication.
- Møller AMJ et al. Septins are critical regulators of osteoclastic bone resorption. Sci Rep 8:13016 (2018). PubMed: 30158637