Key features and details
- Rabbit polyclonal to CATSPER1 - C-terminal
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CATSPER1 antibody - C-terminal
DescriptionRabbit polyclonal to CATSPER1 - C-terminal
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Fusion protein corresponding to Human CATSPER1 (C terminal). (BC032950). The identity of the protein fusion partner is GST.
Database link: Q8NEC5
- Human prostate cancer and thyroid cancer tissues.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197939 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/25 - 1/100.|
FunctionVoltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Involvement in diseaseDefects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7) [MIM:612997]. An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume.
Sequence similaritiesBelongs to the cation channel sperm-associated (TC 1.A.1.19) family.
Developmental stageExpressed meiotically and post-meiotically.
Cellular localizationCell projection > cilium > flagellum membrane. Specifically located in the principal piece of sperm tail.
- Information by UniProt
- Cation channel sperm associated 1 antibody
- Cation channel sperm associated protein 1 antibody
- Cation channel sperm-associated protein 1 antibody
ab197939 has not yet been referenced specifically in any publications.