Anti-CATSPER1 antibody - C-terminal (ab197939)

Overview

  • Product name

    Anti-CATSPER1 antibody - C-terminal
  • Description

    Rabbit polyclonal to CATSPER1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human CATSPER1 (C terminal). (BC032950). The identity of the protein fusion partner is GST.
    Database link: Q8NEC5

  • Positive control

    • Human prostate cancer and thyroid cancer tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG

Applications

Our Abpromise guarantee covers the use of ab197939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Function

    Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
  • Tissue specificity

    Testis-specific.
  • Involvement in disease

    Defects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7) [MIM:612997]. An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume.
  • Sequence similarities

    Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
  • Developmental stage

    Expressed meiotically and post-meiotically.
  • Cellular localization

    Cell projection > cilium > flagellum membrane. Specifically located in the principal piece of sperm tail.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cation channel sperm associated 1 antibody
    • Cation channel sperm associated protein 1 antibody
    • Cation channel sperm-associated protein 1 antibody
    • CATSPER 1 antibody
    • CATSPER antibody
    • CatSper1 antibody
    • CTSR1_HUMAN antibody
    • hCatSper antibody
    • MGC33335 antibody
    • MGC33368 antibody
    • Sperm associated cation channel 1 antibody
    • Sperm ion channel antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue labeling CATSPER1 with ab197939 at 1/40 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling CATSPER1 with ab197939 at 1/40 dilution.

References

ab197939 has not yet been referenced specifically in any publications.

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