Overview

  • Product name

    Anti-CATSPER3 antibody
  • Description

    Rabbit polyclonal to CATSPER3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Fusion protein corresponding to Human CATSPER3 (internal sequence). Gene Accssion: BC110384
    Database link: Q86XQ3

  • Positive control

    • Mouse testis tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab197924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 46 kDa.

Target

  • Function

    Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
  • Tissue specificity

    Testis-specific.
  • Sequence similarities

    Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
  • Cellular localization

    Cell projection > cilium > flagellum membrane. Specifically located in the principal piece of sperm tail.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ca(v)-like protein antibody
    • CACRC antibody
    • calcium channel repeat containing 1 antibody
    • Cation channel sperm-associated protein 3 antibody
    • Cation channel, sperm associated 3 antibody
    • CatSper3 antibody
    • CTSR3_HUMAN antibody
    • One-repeat calcium channel-like protein antibody
    • putative ion channel CatSper3 antibody
    see all

Images

  • Anti-CATSPER3 antibody (ab197924) at 1/350 dilution + Mouse testis lysate at 40 µg

    Predicted band size: 46 kDa


    Exposure time: 2 minutes

References

ab197924 has not yet been referenced specifically in any publications.

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