Anti-Caveolin-1 (phospho Y14) antibody (ab38468)


  • Product name
    Anti-Caveolin-1 (phospho Y14) antibody
    See all Caveolin-1 primary antibodies
  • Description
    Rabbit polyclonal to Caveolin-1 (phospho Y14)
  • Host species
  • Specificity
    This antibody is specific for Caveolin-1 only when phosphorylated at tyrosine 14.
  • Tested applications
    Suitable for: WB, ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Cow, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human Caveolin-1.
    Database link: Q03135

  • Positive control
    • NIH 3T3 cells.



Our Abpromise guarantee covers the use of ab38468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).
ELISA 1/20000.
ICC/IF 1/250.


  • Function
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
  • Tissue specificity
    Expressed in muscle and lung, less so in liver, brain and kidney.
  • Involvement in disease
    Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
  • Sequence similarities
    Belongs to the caveolin family.
  • Post-translational
    The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
  • Cellular localization
    Golgi apparatus membrane. Cell membrane. Membrane > caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
  • Information by UniProt
  • Database links
  • Alternative names
    • BSCL3 antibody
    • CAV antibody
    • CAV1 antibody
    • CAV1_HUMAN antibody
    • caveolae protein, 22 kD antibody
    • caveolin 1 alpha isoform antibody
    • caveolin 1 beta isoform antibody
    • Caveolin 1 caveolae protein 22kDa antibody
    • Caveolin-1 antibody
    • Caveolin1 antibody
    • cell growth-inhibiting protein 32 antibody
    • CGL3 antibody
    • LCCNS antibody
    • MSTP085 antibody
    • OTTHUMP00000025031 antibody
    • PPH3 antibody
    • VIP 21 antibody
    • VIP21 antibody
    see all


  • Lanes 1-2 : Caveolin-1 Antibody
    Lanes 3-4 : Anti-Caveolin-1 (phospho Y14) antibody (ab38468) at 1/500 dilution

    Lane 1 : NIH 3T3 cell extract
    Lane 2 : NIH 3T3 cell extract. Pre-incubated with synthesized peptide
    Lane 3 : NIH 3T3 cell extract.
    Lane 4 : NIH 3T3 cell extract. Treated with H2O2.

    Predicted band size: 20 kDa
    Observed band size: 20 kDa


This product has been referenced in:
  • Bracamontes CG  et al. The serum protein profile of early parity which induces protection against breast cancer. Oncotarget 7:82538-82553 (2016). WB ; Human . Read more (PubMed: 27769065) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for your response.

At this stage it is difficult to identify the source of the problem and to be sure why this antibody failed to work in Western blot application.

It would be interesting to know 1) how well the vial was c...

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My colleague is out of office for the rest of the week. I have tried to review this case and noticed that 2 ul aliquots were prepared. This may contribute to the problem your customer is facing with.

The s...

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Thank you very much for your cooperation. I am sorry to hear this antibody is not providing satisfactory results.

Having reviewed the protocol details again, I believe this product should have given satisfactory results. It is regrettable th...

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Abcam guarantees this product to work in the species/application used in this Abreview.
Immunocytochemistry/ Immunofluorescence
Rat Cell (uterus)
no fixation
Blocking step
BSA as blocking agent for 30 minute(s) · Concentration: 1% · Temperature: 25°C

Abcam user community

Verified customer

Submitted May 07 2012

Thanks you for your email.

This antibody should bind to reduced or denatured form, because we got positive binding for Western blots with the lysates of HuvEc and Hela cells. We haven’t received complains about this antibody. We didn&rs...

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Thank you for your email. I am sorry to hear that you are experiencing problems with this antibody.

I have read the protocol which looks fine to me however I would like to suggest few changes which will help to understand the cause of the pro...

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Abcam guarantees this product to work in the species/application used in this Abreview.
Western blot
Cow Cell lysate - whole cell (Bovine Brain microvascular endothelial cells)
Loading amount
40 µg
Bovine Brain microvascular endothelial cells
Gel Running Conditions
Reduced Denaturing (10% gel)
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

Mr. Cyril Mougin

Verified customer

Submitted Feb 11 2011


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