Anti-Caveolin-3 antibody (ab87770)

Goat polyclonal Caveolin-3 antibody. Validated in WB, IHC and tested in Mouse, Rat, Human, Pig. Immunogen corresponding to synthetic peptide.


  • Product name

  • Description

    Goat polyclonal to Caveolin-3
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human, Pig
    Predicted to work with: Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to Human Caveolin-3 aa 5-18 (N terminal) (Cysteine residue).


    Database link: P56539

  • Positive control

    • Recombinant Human Caveolin-3 protein (ab114264) can be used as a positive control in WB. Human, mouse and rat heart lysates.



Our Abpromise guarantee covers the use of ab87770 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 17 kDa).
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function

    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
  • Tissue specificity

    Expressed predominantly in muscle.
  • Involvement in disease

    Defects in CAV3 are the cause of limb-girdle muscular dystrophy type 1C (LGMD1C) [MIM:607801]. LGMD1C is a myopathy characterized by calf hypertrophy and mild to moderate proximal muscle weakness. LGMD1C inheritance can be autosomal dominant or recessive.
    Defects in CAV3 are a cause of hyperCKmia (HYPCK) [MIM:123320]. It is a disease characterized by persistent elevated levels of serum creatine kinase without muscle weakness.
    Defects in CAV3 are a cause of rippling muscle disease (RMD) [MIM:606072]. RMD is a rare disorder characterized by mechanically triggered contractions of skeletal muscle. In RMD, mechanical stimulation leads to electrically silent muscle contractions that spread to neighboring fibers that cause visible ripples to move over the muscle.
    Defects in CAV3 are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in CAV3 are the cause of long QT syndrome type 9 (LQT9) [MIM:611818]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
    Defects in CAV3 can be a cause of sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Long QT syndromes-associated mutations can be responsible for some SIDS cases.
  • Sequence similarities

    Belongs to the caveolin family.
  • Cellular localization

    Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
  • Information by UniProt
  • Database links

  • Alternative names

    • CAV3 antibody
    • CAV3_HUMAN antibody
    • Caveolin 3 antibody
    • Caveolin-3 antibody
    • LGMD1C antibody
    • LQT9 antibody
    • M-caveolin antibody
    • MGC126100 antibody
    • MGC126101 antibody
    • MGC126129 antibody
    • OTTHUMP00000115603 antibody
    • OTTHUMP00000207105 antibody
    • VIP 21 antibody
    • VIP21 antibody
    see all


  • All lanes : Anti-Caveolin-3 antibody (ab87770) at 0.1 µg/ml

    Lane 1 : pig skeletal muscle tissue lysate
    Lane 2 : pig heart tissue lysate

    Lysates/proteins at 35 µg per lane.

    Predicted band size: 17 kDa
    Observed band size: 20 kDa
    why is the actual band size different from the predicted?

    Detected by chemiluminescence.

  • All lanes : Anti-Caveolin-3 antibody (ab87770) at 0.3 µg/ml

    Lane 1 : mouse heart tissue lysate
    Lane 2 : rat heart tissue lysate

    Lysates/proteins at 35 µg per lane.

    Predicted band size: 17 kDa
    Observed band size: 20 kDa why is the actual band size different from the predicted?

    Detected by chemiluminescence.

  • Anti-Caveolin-3 antibody (ab87770) at 0.3 µg/ml + human heart lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 17 kDa
    Observed band size: 23 kDa why is the actual band size different from the predicted?

    Exposure time: 1 hour

    Detected by chemiluminescence.

  • ab87770 (3.8µg/ml) staining of paraffin embedded Human Skeletal Muscle shows peripheral staining of fibres. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.


ab87770 has not yet been referenced specifically in any publications.

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