Overview

  • Product name

    CAY 10566, SCD1 inhibitor
  • Description

    Potent, selective SCD1 inhibitor
  • Biological description

    Potent, selective SCD1 inhibitor (IC50 values are 4.5 and 26 nM in mouse and human SCD1, respectively). Inhibits saturated, long-chain fatty acyl-CoAs conversion to monounsaturated, long-chain fatty acyl-CoAs (IC50 values are 7.9 and 6.8 nM for heptadecanoic acid and palmitic acid, respectively).
  • Purity

    > 99%
  • CAS Number

    944808-88-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[4-(2-Chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
  • Molecular weight

    389.82
  • Molecular formula

    C18H17ClFN5O2
  • PubChem identifier

    16732433
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=NN=C(O1)C2=NN=C(C=C2)N3CCC(CC3)OC4=C(C=CC(=C4)F)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mohammadzadeh F  et al. Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition. J Breast Cancer 17:136-42 (2014). Read more (PubMed: 25013434) »
  • Masuda M  et al. Activating transcription factor 4 regulates stearate-induced vascular calcification. J Lipid Res 53:1543-52 (2012). Read more (PubMed: 22628618) »
  • Koeberle A  et al. Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol. J Biol Chem 287:27244-54 (2012). Read more (PubMed: 22700983) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144421.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up