Overview

  • Product name

    CAY10567, Akt1 translocation inhibitor
  • Description

    Akt1 translocation inhibitor
  • Biological description

    Akt1 translocation inhibitor. Interferes with the Akt1 PH domain. Inhibits Hepatitis C NS5B RNA-dependent RNA polymerase (IC50 = 79 µM).
  • Purity

    > 98%
  • CAS Number

    32387-96-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,3-Diphenylquinoxaline-6-carboxylic acid
  • Molecular weight

    326.35
  • Molecular formula

    C21H14N2O2
  • PubChem identifier

    629852
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)C(=O)O)N=C2C4=CC=CC=C4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Rong F  et al. Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors. Bioorg Med Chem Lett 17:1663-6 (2007). Read more (PubMed: 17258458) »
  • Lundholt BK  et al. Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer. J Biomol Screen 10:20-9 (2005). Read more (PubMed: 15695340) »
  • Crawford PW  et al. Cyclic voltammetry of phenazines and quinoxalines including mono- and di-N-oxides. Relation to structure and antimicrobial activity. Chem Biol Interact 60:67-84 (1986). Read more (PubMed: 3779885) »

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