CAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor (ab144419)

Overview

  • Product name

    CAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor
  • Description

    Potent dual Cdc7 and Cdk9 kinase inhibitor
  • Alternative names

    • PHA-767491
  • Biological description

    Potent Cdc7 and Cdk9 kinase inhibitor (IC50 values are 10 and 34 nM for Cdc7 in the presence of 1.5 µM ATP and Cdk9 respectively). Induces apoptosis in cancer cell lines. Shows synergistic antitumor effects in vivo with 5-fluorouracil (ab142387).
  • Purity

    > 98%
  • CAS Number

    845714-00-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
  • Molecular weight

    213.24
  • Molecular formula

    C12H11N3O
  • PubChem identifier

    11715767
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li W  et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets 15:196-204 (2015). Read more (PubMed: 25643258) »
  • Natoni A  et al. Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models. Cancers (Basel) 5:901-18 (2013). Read more (PubMed: 24202326) »
  • Natoni A  et al. Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells. Mol Cancer Ther 10:1624-34 (2011). Read more (PubMed: 21768328) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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