Key features and details
- Potent dual Cdc7 and Cdk9 kinase inhibitor
- CAS Number: 845714-00-3
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameCAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor
DescriptionPotent dual Cdc7 and Cdk9 kinase inhibitor
Biological descriptionPotent Cdc7 and Cdk9 kinase inhibitor (IC50 values are 10 and 34 nM for Cdc7 in the presence of 1.5 µM ATP and Cdk9 respectively). Induces apoptosis in cancer cell lines. Shows synergistic antitumor effects in vivo with 5-fluorouracil (ab142387).
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144419 has not yet been referenced specifically in any publications.