Overview

  • Product name

    CAY10598, EP4 agonist
  • Description

    Potent, selective EP4 agonist
  • Biological description

    Potent, selective EP4 agonist (Ki = 1.2 nM). Demonstrates p53 and Bax induction, cytochrome c release and caspase-9, -7, and -3 and PARP cleavage. Inhibits Bcl-2, Bcl-xL and survivin expression. Induces apoptosis. Inhibits JAK2/STAT3 signaling. Generates ROS. Shows inflammatory effects in vivo.
  • Purity

    > 98%
  • CAS Number

    346673-06-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tang EH  et al. Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue. J Lipid Res 56:358-68 (2015). Read more (PubMed: 25510249) »
  • Eskildsen MP  et al. Prostaglandin I2 and prostaglandin E2 modulate human intrarenal artery contractility through prostaglandin E2-EP4, prostacyclin-IP, and thromboxane A2-TP receptors. Hypertension 64:551-6 (2014). Read more (PubMed: 24914192) »
  • Chae IG  et al. Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. Free Radic Res 48:1311-21 (2014). Read more (PubMed: 25096910) »

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