Overview

  • Product name

    CAY10602, SIRT1 Activator
  • Description

    SIRT1 Activator
  • Biological description

    SIRT1 Activator. Suppresses NF-κB-dependent induction of TNF-α by LPS (IC70 = 60 μM, THP-1 cells). Upregulates PPARδ-mediated transcription in ECs.
  • Purity

    > 95%
  • CAS Number

    374922-43-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(Benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine
  • Molecular weight

    418.44
  • Molecular formula

    C22H15FN4O2S
  • PubChem identifier

    1915791
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)S(=O)(=O)C2=C(N(C3=NC4=CC=CC=C4N=C23)C5=CC=C(C=C5)F)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Höppner S  et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom 27:35-50 (2013). Read more (PubMed: 23239315) »
  • Nayagam VM  et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11:959-67 (2006). Read more (PubMed: 17099246) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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