Overview

  • Product name

  • Description

    Rabbit polyclonal to Cbl-c
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment within Human Cbl-c (internal sequence). The exact sequence is proprietary.
    Database link: Q9ULV8

  • Positive control

    • WB: Mouse kidney extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab228785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 52 kDa.

Target

  • Relevance

    Cblc belongs to a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cblc is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitous). Cblc, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cblc knock out mice show no obvious phenotype. Thus, the physiological role of Cblc is not known.
  • Cellular localization

    Nuclear
  • Database links

  • Alternative names

    • Cas Br M (murine) ecotropic retroviral transforming sequence c antibody
    • Cas Br M (murine) ectropic retroviral transforming sequence c antibody
    • Casitas B lineage lymphoma c antibody
    • CBL 3 antibody
    • Cbl proto-oncogene C, E3 ubiquitin protein ligase antibody
    • Cbl proto-oncogene, E3 ubiquitin protein ligase C antibody
    • CBL SL antibody
    • E3 ubiquitin-protein ligase CBL-C antibody
    • RING finger protein 57 antibody
    • RNF57 antibody
    • SH3 binding protein CBL C antibody
    • SH3-binding protein CBL-3 antibody
    • Signal transduction protein CBL C antibody
    see all

Images

  • Anti-Cbl-c antibody (ab228785) at 1/1000 dilution + Mouse kidney extract at 50 µg

    Predicted band size: 52 kDa



    10% SDS-PAGE gel.

References

ab228785 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228785.
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