• Product name
  • Description
    Rabbit polyclonal to CBLB
  • Host species
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the center region of Human CBLB (NP_733762.2).

  • Positive control
    • HL-60 cell line lysate



Our Abpromise guarantee covers the use of ab93205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 109 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Tissue specificity: Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level). Pathway: Protein modification; protein ubiquitination. Similarity: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain. Contains 1 RING-type zinc finger. Contains 1 UBA domain. Domain: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. The UBA domain interacts with poly-ubiquitinated proteins. PTM: Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation. Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes proteasomal degradation.
    • Cellular localization
      Cytoplasmic and Nuclear
    • Database links
    • Alternative names
      • AI429560 antibody
      • AI851073 antibody
      • Cas Br M (murine) ecotropic retroviral transforming sequence b antibody
      • Casitas B lineage lymphoma b antibody
      • Casitas B lineage lymphoma proto oncogene b antibody
      • Casitas B-lineage lymphoma proto-oncogene b antibody
      • Cbl b antibody
      • CBLB antibody
      • CBLB_HUMAN antibody
      • DKFZp686J10223 antibody
      • DKFZp779A0729 antibody
      • DKFZp779F1443 antibody
      • E3 ubiquitin protein ligase CBL B antibody
      • E3 ubiquitin-protein ligase CBL-B antibody
      • EC 6.3.2.- antibody
      • FLJ36865 antibody
      • FLJ41152 antibody
      • Nbla00127 antibody
      • RING finger protein 56 antibody
      • RNF56 antibody
      • SH3 binding protein CBL B antibody
      • SH3-binding protein CBL-B antibody
      • Signal transduction protein CBL B antibody
      • Signal transduction protein CBL-B antibody
      see all


    • Anti-CBLB antibody (ab93205) at 1/100 dilution + HL-60 cell line lysate at 35 µg

      Predicted band size: 109 kDa


    ab93205 has not yet been referenced specifically in any publications.

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