Overview

  • Product name

  • Description

    Rabbit polyclonal to CBR1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human CBR1 aa 1-277.
    Database link: P16152

  • Positive control

    • SW480, 22RV1, MCF7, H460, SKOV3, Mouse kidney, Mouse liver, Mouse lung and Mouse testis cell line extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab186825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 30 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
  • Sequence similarities

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • 15 hydroxyprostaglandin dehydrogenase [NADP+] antibody
    • 15-hydroxyprostaglandin dehydrogenase [NADP+] antibody
    • Carbonyl reductase [NADPH] 1 antibody
    • Carbonyl Reductase 1 antibody
    • CBR 1 antibody
    • CBR1 antibody
    • CBR1_HUMAN antibody
    • CRN antibody
    • NADPH dependent carbonyl reductase 1 antibody
    • NADPH-dependent carbonyl reductase 1 antibody
    • Prostaglandin 9 ketoreductase antibody
    • Prostaglandin 9-ketoreductase antibody
    • Prostaglandin E(2) 9 reductase antibody
    • Prostaglandin-E(2) 9-reductase antibody
    • SDR21C1 antibody
    see all

Images

  • All lanes : Anti-CBR1 antibody (ab186825) at 1/500 dilution

    Lane 1 : SW480 cell line extract
    Lane 2 : 22RV1 cell line extract
    Lane 3 : MCF7 cell line extract
    Lane 4 : H460 cell line extract
    Lane 5 : SKOV3 cell line extract
    Lane 6 : Mouse kidney cell line extract
    Lane 7 : Mouse liver cell line extract
    Lane 8 : Mouse lung cell line extract
    Lane 9 : Mouse testis cell line extract

    Predicted band size: 30 kDa

References

ab186825 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab186825.
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