Anti-CBX2 antibody (ab182620)
Key features and details
- Rabbit polyclonal to CBX2
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-CBX2 antibody
See all CBX2 primary antibodies -
Description
Rabbit polyclonal to CBX2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant full length protein corresponding to Human CBX2 aa 1-250.
Database link: Q14781-1 -
Positive control
- Human ovarian cancer tissue lysate, Mouse heart tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab182620 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/350 - 1/2000. Predicted molecular weight: 56 kDa.
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Notes |
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WB
1/350 - 1/2000. Predicted molecular weight: 56 kDa. |
Target
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Function
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. -
Involvement in disease
Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:613080]. It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. -
Sequence similarities
Contains 1 A.T hook DNA-binding domain.
Contains 1 chromo domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 84733 Human
- Entrez Gene: 12416 Mouse
- Omim: 602770 Human
- SwissProt: Q14781 Human
- SwissProt: P30658 Mouse
- Unigene: 368410 Human
- Unigene: 14547 Mouse
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Alternative names
- Cbx 2 antibody
- CBX2 antibody
- CBX2_HUMAN antibody
see all
Images
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All lanes : Anti-CBX2 antibody (ab182620) at 1/350 dilution
Lane 1 : Human ovarian cancer tissue lysate
Lane 2 : Mouse heart tissue lysate
Lysates/proteins at 30 µg per lane.
Secondary
All lanes : Goat anti Rabbit IgG - H&L HRP conjugated antibody at 1/10000 dilution
Developed using the ECL technique.
Predicted band size: 56 kDa
Exposure time: 20 seconds
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab182620 has been referenced in 1 publication.
- Zhu J et al. Circ_0061140 knockdown inhibits tumorigenesis and improves PTX sensitivity by regulating miR-136/CBX2 axis in ovarian cancer. J Ovarian Res 14:136 (2021). PubMed: 34649611