Overview

  • Product name

  • Description

    Rabbit polyclonal to CBX2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein corresponding to Human CBX2 aa 1-211. Isoform 2 (BC004252).
    Sequence:

    MEELSSVGEQ VFAAECILSK RLRKGKLEYL VKWRGWSSKH NSWEPEENIL DPRLLLAFQK KEHEKEVQNR KRGKRPRGRP RKLTAMSSCS RRSKLKVGGC AGYADPTSQH PLGVGGRQRE GLGPSGRGWH FCQQSVPLLG KQEPPFFLSL SFCCQGPQPA ESSSPPLPGA SCFSLSCTPL CWVAGSNCCR QALFPPRGSL GDGKEQEACV Q


    Database link: Q14781-2

  • Positive control

    • Human ovarian cancer tissue lysate, Mouse heart tissue lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol

    without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab182620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/350 - 1/2000. Predicted molecular weight: 56 kDa.

Target

  • Function

    Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
  • Involvement in disease

    Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:613080]. It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.
  • Sequence similarities

    Contains 1 A.T hook DNA-binding domain.
    Contains 1 chromo domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cbx 2 antibody
    • CBX2 antibody
    • CBX2_HUMAN antibody
    • CDC A6 antibody
    • CDCA6 antibody
    • Cell division cycle associated 6 antibody
    • Cell division cycle associated6 antibody
    • chromobox homolog 2 (Pc class homolog, Drosophila) antibody
    • Chromobox homolog 2 antibody
    • Chromobox homolog2 antibody
    • Chromobox protein homolog 2 antibody
    • hromobox homolog 2 antibody
    • M33 antibody
    • M33 polycomb like antibody
    • MOD 2 antibody
    • MOD2 antibody
    • Modifier 3 antibody
    • Modifier3 antibody
    • Pc class homolog antibody
    • Polycomb antibody
    • SRXY5 antibody
    see all

Images

  • All lanes : Anti-CBX2 antibody (ab182620) at 1/350 dilution

    Lane 1 : Human ovarian cancer tissue lysate
    Lane 2 : Mouse heart tissue lysate

    Lysates/proteins at 30 µg per lane.

    Secondary
    All lanes : Goat anti Rabbit IgG - H&L HRP conjugated antibody at 1/10000 dilution

    Developed using the ECL technique.

    Predicted band size: 56 kDa


    Exposure time: 20 seconds

References

ab182620 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab182620.
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