Product nameAnti-CBX2 antibody
See all CBX2 primary antibodies
DescriptionRabbit polyclonal to CBX2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Human
Recombinant full length protein corresponding to Human CBX2 aa 1-211. Isoform 2 (BC004252).
MEELSSVGEQ VFAAECILSK RLRKGKLEYL VKWRGWSSKH NSWEPEENIL DPRLLLAFQK KEHEKEVQNR KRGKRPRGRP RKLTAMSSCS RRSKLKVGGC AGYADPTSQH PLGVGGRQRE GLGPSGRGWH FCQQSVPLLG KQEPPFFLSL SFCCQGPQPA ESSSPPLPGA SCFSLSCTPL CWVAGSNCCR QALFPPRGSL GDGKEQEACV Q
Database link: Q14781-2
- Human ovarian cancer tissue lysate, Mouse heart tissue lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.3
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol
without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab182620 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/350 - 1/2000. Predicted molecular weight: 56 kDa.|
FunctionComponent of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
Involvement in diseaseDefects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:613080]. It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.
Sequence similaritiesContains 1 A.T hook DNA-binding domain.
Contains 1 chromo domain.
- Information by UniProt
- Cbx 2 antibody
- CBX2 antibody
- CBX2_HUMAN antibody
All lanes : Anti-CBX2 antibody (ab182620) at 1/350 dilution
Lane 1 : Human ovarian cancer tissue lysate
Lane 2 : Mouse heart tissue lysate
Lysates/proteins at 30 µg per lane.
All lanes : Goat anti Rabbit IgG - H&L HRP conjugated antibody at 1/10000 dilution
Developed using the ECL technique.
Predicted band size: 56 kDa
Exposure time: 20 seconds
ab182620 has not yet been referenced specifically in any publications.