Key features and details
- Rabbit polyclonal to CBX4
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-CBX4 antibody
See all CBX4 primary antibodies
DescriptionRabbit polyclonal to CBX4
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Opossum, Chinese hamster
Synthetic peptide, corresponding to a region between amino acids 150-200 of Human CBX4 (NP_003646.2).
- Human Breast Carcinoma, Ovarian Carcinoma and Prostate Carcinoma tissues; Mouse Renal Cell Carcinoma and Teratoma tissues
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris buffered saline, 0.1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab114038 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.|
FunctionE3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
PathwayProtein modification; protein sumoylation.
Sequence similaritiesContains 1 chromo domain.
modificationsPhosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494.
- Information by UniProt
- CBX 4 antibody
- CBX4 antibody
- Cbx4 chromobox homolog 4 (Drosophila Pc class) antibody
ab114038, at 1/250 dilution, staining CBX4 in formalin-fixed, paraffin-embedded Human Breast Carcinoma tissue by Immunohistochemistry with DAB staining.
ab114038, at 1/250 dilution, staining CBX4 in formalin-fixed, paraffin-embedded Mouse renal cell carcinoma tissue by Immunohistochemistry with DAB staining.
ab114038 has not yet been referenced specifically in any publications.