Overview

  • Product name

  • Description

    Mouse monoclonal to CBX4
  • Host species

    Mouse
  • Specificity

    ab200942 was developed against a fully folded protein domain, so it does not show good reactivity against denatured proteins, and may not work in western blot applications.
  • Tested applications

    Suitable for: MS, IPmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment corresponding to Human CBX4 aa 8-65.
    Sequence:

    EHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR ERQEQ


    Database link: O00257

  • Positive control

    • HEK293 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab200942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
MS Use at an assay dependent concentration.
IP Use at an assay dependent concentration.

2 μg per IP

Target

  • Function

    E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
  • Tissue specificity

    Ubiquitous.
  • Pathway

    Protein modification; protein sumoylation.
  • Sequence similarities

    Contains 1 chromo domain.
  • Post-translational
    modifications

    Phosphorylated on Thr-497 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • CBX 4 antibody
    • CBX4 antibody
    • Cbx4 chromobox homolog 4 (Drosophila Pc class) antibody
    • CBX4_HUMAN antibody
    • Chromobox homolog 4 (Pc class homolog, Drosophila) antibody
    • Chromobox homolog 4 antibody
    • Chromobox protein homolog 4 antibody
    • E3 SUMO protein ligase CBX 4 antibody
    • E3 SUMO protein ligase CBX4 antibody
    • E3 SUMO-protein ligase CBX4 antibody
    • hPc 2 antibody
    • hPc2 antibody
    • NBP 16 antibody
    • NBP16 antibody
    • NS5ATP1 binding protein 16 antibody
    • Pc 2 antibody
    • Pc class 2 homolog antibody
    • Pc class homolog antibody
    • Pc class homolog Drosophila antibody
    • PC2 antibody
    • Polycomb 2 homolog antibody
    see all

References

ab200942 has not yet been referenced specifically in any publications.

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