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I am interested in possibly using your CBX7 antibody (ab21873) in zebrafish. I was interested in this CBX7 antibody, in particular, since it seems have a more wide range of predicted species reactivity than your other CBX7 antibodies. I noticed that the epitope resides within 200 of the C-terminus of Human CBX7. What human CBX7 protein is this as there are three present in ensemble? My assumption is that it is CBX7-001 as it is the only protein > 200 amino acids.
Or, I have included the zebrafish CBX7 protein sequence below? Could you make any inferences about reactivity based on the % similarity of your product with the ZF protein?
Lastly, if you think this antibody would not be ideal, do any of your other CBX7 antibodies have more % similarity with the ZF protein?
Asked on Jun 13 2012
The immunogen is derived from the human CBX7 at the following UniProt entry URL:
Alignment of the immunogen with the sequence provided gave poor results.
Unfortunately, alignments of the immunogens of three of four of our other antibodies against this protein were worse. I am waiting for the result for the fourth, ab123492, which I will send when I receive it.
Please do not hesitate to contact us if you need any more advice or information.
Answered on Jun 13 2012