Overview

  • Product name

    CC-401, ATP-competitive JNK inhibitor
  • Description

    ATP-competitive, selective JNK inhibitor
  • Biological description

    ATP-competitive, selective JNK inhibitor. Decreases c-Jun transcription activity and proliferation. Decreases cytochrome c release and caspase 3 activation. Shows anti-ischemic, anti-inflammatory and antiapoptotic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    1438391-30-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole hydrochloride
  • Molecular weight

    424.93
  • Molecular formula

    C22H24N6O.HCl
  • PubChem identifier

    66576998
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gan LT  et al. Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent. J Hepatol : (2014). Read more (PubMed: 25064435) »
  • Kanellis J  et al. JNK signalling in human and experimental renal ischaemia/reperfusion injury. Nephrol Dial Transplant 25:2898-908 (2010). Read more (PubMed: 20368303) »
  • Ma FY  et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest 89:470-84 (2009). Read more (PubMed: 19188913) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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