• Product name

  • Description

    Rabbit polyclonal to CC2D1A
  • Host species

  • Tested applications

    Suitable for: WB, IP, IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residues 1 and 50 of human CC2D1A

  • Positive control

    • Whole cell lysate from 293T cells. NETN or RIPA lysate from HeLa cells.



Our Abpromise guarantee covers the use of ab70375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 130 kDa (predicted molecular weight: 104 kDa).
IP Use at 3-10 µg/mg of lysate.
IHC-P 1/500 - 1/2000. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
ICC 1/100.


  • Relevance

    CC2D1A belongs to the CC2D1 family. It contains one C2 domain. It is a transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. CC2D1A may play a role in the altered regulation of HTR1A associated with anxiety and major depression. It also mediates HDAC-independent repression of HTR1A promoter in neuronal cell. There are three named isoforms. Defects in CC2D1A are the cause of non-syndromic mental retardation autosomal recessive type 3 (MRT3). Patients display severe mental retardation and psychomotor development delay in early childhood. Non-syndromic mental retardation patients do not manifest other clinical signs.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Database links

  • Alternative names

    • Akt kinase interacting protein 1 antibody
    • Coiled coil and C2 domain containing 1A antibody
    • Coiled coil and C2 domain containing protein 1A antibody
    • Five repressor element under dual repression binding protein 1 antibody
    • FLJ20241 antibody
    • FLJ41160 antibody
    • FRE under dual repression binding protein 1 antibody
    • FREUD 1 antibody
    • Freud 1/Aki1 antibody
    • Mental retardation, nonsyndromic, autosomal recessive, 3 antibody
    • MRT3 antibody
    • Putative NF kappa B activating protein 023N antibody
    • Putative NF kappa B activating protein antibody
    see all


  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue labelling CC2D1A with ab70375 at 1/1000 (1µg/ml). Detection: DAB.
  • Anti-CC2D1A antibody (ab70375) at 0.3 µg/ml + Whole cell lysate from 293T cells at 50 µg

    Predicted band size: 104 kDa
    Observed band size: 130 kDa
    why is the actual band size different from the predicted?
    Additional bands at: 105 kDa, 120 kDa, 90 kDa. We are unsure as to the identity of these extra bands.

  • Detection of Human CC2D1A by Immunoprecipitiaton. ab70375 used at 20 µg/50 mg NETN or RIPA lysate from HeLa cells. Immunoprecipitate was resolved by SDS-PAGE and the band that is CC2D1A was confirmed by mass spectrometry.


ab70375 has not yet been referenced specifically in any publications.

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