Overview

  • Product name
    Anti-CCDC39 antibody - C-terminal
    See all CCDC39 primary antibodies
  • Description
    Rabbit polyclonal to CCDC39 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Chinese hamster
    Predicted to work with: Dog, Human
  • Immunogen

    Synthetic peptide within Human CCDC39 aa 770-798 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9UFE4

  • Positive control
    • CHO and NIH 3T3 cell lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab170284 is purified through a protein A column, followed by immunogen affinity purification
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170284 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 110 kDa.

Target

  • Function
    Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly.
  • Tissue specificity
    Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis.
  • Involvement in disease
    Defects in CCDC39 are the cause of primary ciliary dyskinesia type 14 (CILD14) [MIM:613807]. A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • Sequence similarities
    Belongs to the CCDC39 family.
  • Cellular localization
    Cytoplasm > cytoskeleton > cilium axoneme. CCDC40 is required for localization to axonemes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CCD39_HUMAN antibody
    • Ccdc39 antibody
    • CILD141 antibody
    • Coiled-coil domain-containing protein 39 antibody
    • DKFZp434A128 antibody
    • FAP59 antibody
    see all

Images

  • Anti-CCDC39 antibody - C-terminal (ab170284) at 1/100 dilution + NIH 3T3 cell lysate at 35 µg

    Secondary
    Anti-rabbit HRP conjugated antibody at 1/10000 dilution

    Developed using the ECL technique.

    Predicted band size: 110 kDa

  • Anti-CCDC39 antibody - C-terminal (ab170284) at 1/100 dilution + CHO cell lysate at 35 µg

    Secondary
    Anti-rabbit HRP conjugated antibody at 1/10000 dilution

    Developed using the ECL technique.

    Predicted band size: 110 kDa

References

ab170284 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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