Overview

  • Product name

  • Description

    Rabbit polyclonal to CCDC6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human CCDC6 aa 375-425. The exact sequence is proprietary. AAC60637.1
    Database link: Q16204

  • Positive control

    • IP: HeLa whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab245534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Tissue specificity

      Ubiquitously expressed.
    • Involvement in disease

      Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
    • Domain

      The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.
    • Cellular localization

      Cytoplasm. Cytoplasm > cytoskeleton. May be a cytoskeletal protein.
    • Information by UniProt
    • Database links

    • Alternative names

      • CCDC 6 antibody
      • CCDC6 antibody
      • CCDC6_HUMAN antibody
      • Coiled coil domain containing 6 antibody
      • Coiled coil domain containing protein 6 antibody
      • Coiled-coil domain-containing protein 6 antibody
      • D10S170 antibody
      • FLJ32286 antibody
      • H4 antibody
      • Papillary thyroid carcinoma encoded protein antibody
      • Papillary thyroid carcinoma-encoded protein antibody
      • Protein H4 antibody
      • PTC antibody
      • TPC antibody
      • TST 1 antibody
      • TST1 antibody
      see all

    Images

    • CCDC6 was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab245534 at 3 µg/mg lysate. Western blot was performed from the immunoprecipitate using a different Anti-CCDC6 antibody at 1 µg/ml.

      Lane 1: ab245534 IP in HeLa whole cell lysate.
      Lane 2: Control IgG IP in HeLa whole cell lysate.

      Detection: Chemiluminescence with exposure time of 10 seconds.

    References

    ab245534 has not yet been referenced specifically in any publications.

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