Key features and details
- Rabbit polyclonal to CCDC6
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CCDC6 antibody
See all CCDC6 primary antibodies
DescriptionRabbit polyclonal to CCDC6
Tested applicationsSuitable for: IPmore details
Species reactivityReacts with: Human
Synthetic peptide within Human CCDC6 aa 375-425. The exact sequence is proprietary. AAC60637.1
Database link: Q16204
- IP: HeLa whole cell lysate.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7
Preservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate
pH 7 to 8
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab245534 was affinity purified using an epitope specific to CCDC6 immobilized on solid support.
Our Abpromise guarantee covers the use of ab245534 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at 2-5 µg/mg of lysate.|
Tissue specificityUbiquitously expressed.
Involvement in diseaseDefects in CCDC6 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
DomainThe protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.
Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. May be a cytoskeletal protein.
- Information by UniProt
- CCDC 6 antibody
- CCDC6 antibody
- CCDC6_HUMAN antibody
CCDC6 was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab245534 at 3 µg/mg lysate. Western blot was performed from the immunoprecipitate using a different Anti-CCDC6 antibody at 1 µg/ml.
Lane 1: ab245534 IP in HeLa whole cell lysate.
Lane 2: Control IgG IP in HeLa whole cell lysate.
Detection: Chemiluminescence with exposure time of 10 seconds.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab245534 has not yet been referenced specifically in any publications.