CCG 1423, Rho pathway-mediated signaling inhibitor (ab229181)

Overview

  • Product name

    CCG 1423, Rho pathway-mediated signaling inhibitor
  • Description

    Specific inhibitor of Rho pathway-mediated signaling and activation SRF transcription
  • Alternative names

    • N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide
  • Biological description

    Specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Displays activity in several in vitro cancer cell functional assays. Potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, inhibits growth of RhoC-overexpressing melanoma lines at nanomolar concentrations. Selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell lines. Acts at or downstream of MLK1 and upstream of SRF. Blocks MLK1 nuclear localization.

  • Purity

    > 98%
  • CAS Number

    285986-88-1

Properties

  • Chemical name

    N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide
  • Molecular weight

    454.75
  • Molecular formula

    C18H13ClF6N2O3
  • PubChem identifier

    2726015
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C(=O)NC1=CC=C(C=C1)Cl)ONC(=O)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F
  • Source

    Synthetic

References

ab229181 has not yet been referenced specifically in any publications.

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