Overview

  • Product name

    CCK-4, CCKB receptor agonist
  • Description

    Selective CCKB receptor agonist
  • Biological description

    Selective cholecystokinin B (CCKB) receptor agonist. Increases secretory activity of mast cells. Anxiogenic agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    1947-37-1
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    596.70
  • Molecular formula

    C29H36N6O6S
  • Sequence

    WMDF (Modifications: C-terminal amide)
  • PubChem identifier

    446569
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 1 mg/ml
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CSCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Pérez de la Mora M  et al. Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and [3H]GABA release. Eur J Neurosci 26:3614-30 (2007). Read more (PubMed: 18088282) »
  • Tsujino N  et al. Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci 25:7459-69 (2005). Read more (PubMed: 16093397) »
  • Smirnova EA  et al. Effects of cholecystokinin-4 on secretory activity of rat mast cells. Bull Exp Biol Med 135:12-5 (2003). Read more (PubMed: 12717501) »

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