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    cck1-r-antibody-ab77269.pdf

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Neuroscience Neurology process Neurodegenerative disease Parkinson's disease Other
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Anti-CCK1-R antibody (ab77269)

  • Datasheet
Reviews (1) Submit a question References (1)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCK1-R antibody (ab77269)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCK1-R antibody (ab77269)

Key features and details

  • Goat polyclonal to CCK1-R
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)

View more associated products

Overview

  • Product name

    Anti-CCK1-R antibody
    See all CCK1-R primary antibodies
  • Description

    Goat polyclonal to CCK1-R
  • Host species

    Goat
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to Human CCK1-R aa 242-257 (internal sequence).
    Sequence:

    C-FEASQKKSAKERKPST


    Database link: NP_000721.1
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes

    Protein previously labeled as CCKAR.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab77269 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Parkinson's disease
    • Other
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Alzheimer's disease
    • Other
    • Neuroscience
    • Neurology process
    • Metabolism
    • Metabolism
    • Types of disease
    • Neurodegenerative disease
    • Metabolism
    • Types of disease
    • Obesity
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Compatible Secondaries

    • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
    • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
  • Isotype control

    • Goat IgG, polyclonal - Isotype Control (ab37373)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab77269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Human
Application Abreviews Notes
IHC-P (1)
Use a concentration of 2 - 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Notes
IHC-P
Use a concentration of 2 - 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession P32238 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 886 Human
    • Omim: 118444 Human
    • SwissProt: P32238 Human
    • Unigene: 129 Human
    • Alternative names

      • CCK A antibody
      • CCK A receptor antibody
      • CCK AR antibody
      • CCK-A receptor antibody
      • CCK-AR antibody
      • CCK1 R antibody
      • CCK1-R antibody
      • CCK1R antibody
      • CCKA antibody
      • CCKA receptor antibody
      • CCKAR antibody
      • CCKAR_HUMAN antibody
      • CCKR Type A antibody
      • CCKRA antibody
      • Cholecystokinin 1 receptor antibody
      • Cholecystokinin A receptor antibody
      • Cholecystokinin receptor type A antibody
      • Cholecystokinin type A receptor antibody
      • Cholecystokinin-1 receptor antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCK1-R antibody (ab77269)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCK1-R antibody (ab77269)

      ab77269 (4 µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCK1-R antibody (ab77269)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCK1-R antibody (ab77269)

      ab77269 at 10 µg/ml staining CCK1-R in human pancreas by Immunohistochemistry, Paraffin-embedded tissue (note cytoplasmic staining of some cells in the islets of Langerhans).

    Protocols

    • Immunohistochemistry protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab77269? Please let us know so that we can cite the reference in this datasheet.

    ab77269 has been referenced in 1 publication.

    • El-Kouhen K & Morisset J Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line. Pancreas 39:127-34 (2010). ICC/IF . PubMed: 19959964

    Customer reviews and Q&As

    Show All Reviews Q&A
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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-CCK1-R antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Cat Tissue sections (Pancreas)
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citrate Buffer
    Permeabilization
    Yes - Triton X-100
    Specification
    Pancreas
    Blocking step
    Serum as blocking agent for 12 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 19°C
    Fixative
    Formaldehyde
    Read More

    Ms. Alison Holiday

    Verified customer

    Submitted Feb 07 2018

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