- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-CCM2 antibody
See all CCM2 primary antibodies -
DescriptionRabbit polyclonal to CCM2
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Host speciesRabbit
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
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Immunogen
Recombinant protein fragment, corresponding to a region within amino acids 28-303 of Human CCM2 (UniProt ID: Q9BSQ5).
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Positive control
- 293T cell lysate.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78% PBS, 20% Glycerol, 1% BSA -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab155660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 49 kDa. |
Target
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FunctionMay function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
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Involvement in diseaseDefects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
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Sequence similaritiesContains 1 PID domain.
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Cellular localizationCytoplasm.
- Information by UniProt
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Database links
- Entrez Gene: 83605 Human
- Entrez Gene: 216527 Mouse
- Entrez Gene: 305505 Rat
- Omim: 607929 Human
- SwissProt: Q9BSQ5 Human
- SwissProt: Q8K2Y9 Mouse
- Unigene: 148272 Human
- Unigene: 221271 Mouse
see all -
Alternative names
- C7orf22 antibody
- Ccm2 antibody
- CCM2 gene antibody
see all
Images
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Western blot - Anti-CCM2 antibody (ab155660)Anti-CCM2 antibody (ab155660) at 1/1000 dilution + 293T whole cell lysate at 30 µg
Predicted band size: 49 kDa
10% SDS PAGE
Protocols
References
ab155660 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"