Overview

  • Product name

  • Description

    Rabbit polyclonal to CCM2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human CCM2 aa 1-300.
    Database link: Q9BSQ5

  • Positive control

    • IHC-P: Human cervical cancer tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab229813 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
  • Involvement in disease

    Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • Sequence similarities

    Contains 1 PID domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • C7orf22 antibody
    • Ccm2 antibody
    • CCM2 gene antibody
    • CCM2_HUMAN antibody
    • Cerebral cavernous malformation 2 antibody
    • Cerebral cavernous malformations 2 protein antibody
    • Chromosome 7 open reading frame 22 antibody
    • Malcavernin antibody
    • MGC4067 antibody
    • MGC4607 antibody
    • MGC74868 antibody
    • OSM antibody
    • Osmosensing scaffold for MEKK3 antibody
    • OTTHUMP00000159554 antibody
    • OTTHUMP00000214270 antibody
    • OTTHUMP00000214271 antibody
    • OTTHUMP00000214273 antibody
    • PP10187 antibody
    see all

Images

  • Paraffin-embedded human cervical cancer tissue stained for CCM2 using ab229813 at 1/100 dilution in immunohistochemical analysis.

References

ab229813 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab229813.
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