Anti-CCNDBP1 antibody (ab220275)
Key features and details
- Rabbit polyclonal to CCNDBP1
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-CCNDBP1 antibody
See all CCNDBP1 primary antibodies -
Description
Rabbit polyclonal to CCNDBP1 -
Host species
Rabbit -
Tested applications
Suitable for: ICC/IF, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Cynomolgus monkey, Orangutan -
Immunogen
Recombinant fragment corresponding to Human CCNDBP1 aa 100-250.
Database link: Q4R809 -
Positive control
- RT-4 cell lysate; A431 cells.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab220275 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
|
|
WB |
Use a concentration of 0.04 - 0.4 µg/ml. Predicted molecular weight: 40 kDa.
|
Notes |
---|
ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
WB
Use a concentration of 0.04 - 0.4 µg/ml. Predicted molecular weight: 40 kDa. |
Target
-
Function
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. -
Tissue specificity
Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. -
Sequence similarities
Belongs to the CCNDBP1 family. -
Developmental stage
Expression may increase during differentiation. -
Post-translational
modificationsPhosphorylated. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
-
Database links
- Entrez Gene: 101866754 Cynomolgus monkey
- Entrez Gene: 23582 Human
- Entrez Gene: 100171439 Orangutan
- Omim: 607089 Human
- SwissProt: Q4R809 Cynomolgus monkey
- SwissProt: O95273 Human
- SwissProt: Q5RFN4 Orangutan
- Unigene: 36794 Human
-
Alternative names
- AU022347 antibody
- CCDB1_HUMAN antibody
- CCNDBP 1 antibody
see all
Images
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (2)
ab220275 has been referenced in 2 publications.
- Niwa Y et al. Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM-CHK2 Pathway. J Clin Med 11:N/A (2022). PubMed: 35160302
- Tan C et al. Activation of PTGS2/NF-?B signaling pathway enhances radiation resistance of glioma. Cancer Med 8:1175-1185 (2019). PubMed: 30740906