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    ccr3-antibody-ab25789.pdf

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Immunology Innate Immunity Chemokines Beta Chemokine Rec. (CCR)
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Anti-CCR3 antibody (ab25789)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR3 antibody (ab25789)

    Key features and details

    • Goat polyclonal to CCR3
    • Suitable for: IHC-P
    • Reacts with: Mouse
    • Isotype: IgG

    Get better batch-to-batch reproducibility with a recombinant antibody

    Product image
    Anti-CCR3 antibody [Y31] - Low endotoxin, Azide free (ab228341)
    • Research with confidence – consistent and reproducible results with every batch
    • Long-term and scalable supply – powered by recombinant technology for fast production
    • Success from the first experiment – confirmed specificity through extensive validation
    • Ethical standards compliant – production is animal-free

    Overview

    • Product name

      Anti-CCR3 antibody
      See all CCR3 primary antibodies
    • Description

      Goat polyclonal to CCR3
    • Host species

      Goat
    • Specificity

      This antibody recognizes mouse CCR3 and the peptide sequence is < 50 % identical to other chemokine receptors in this region.
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Mouse
    • Immunogen

      Synthetic peptide:

      TDEIKTVVESFETTPYEYEWAPPC

      , corresponding to N terminal amino acids 5-29 of Mouse CCR3
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Human spleen sections or cytosmears/cytospins of human peripheral blood leukocytes. A549 cell line also has been shown to express CCR3 receptor.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    • Storage buffer

      pH: 7.20
      Preservative: 0.1% Sodium azide
      Constituents: 0.21% Potassium phosphate, 0.812% Sodium chloride, 0.1% BSA
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Immunology
      • Innate Immunity
      • Chemokines
      • Beta Chemokine Rec. (CCR)
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Immunology
      • Immune System Diseases
      • Antiviral Signaling
      • HIV-related

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab25789 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use at an assay dependent concentration.
    Notes
    IHC-P
    Use at an assay dependent concentration.

    Target

    • Function

      Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
    • Tissue specificity

      In eosinophils as well as trace amounts in neutrophils and monocytes.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession P51677 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 12771 Mouse
      • SwissProt: P51678 Mouse
      • Alternative names

        • B chemokine receptor antibody
        • b-chemokine receptor antibody
        • C C chemokine receptor type 3 antibody
        • C C CKR 3 antibody
        • C-C chemokine receptor type 3 antibody
        • C-C CKR-3 antibody
        • CC chemokine receptor 3 antibody
        • CC chemokine receptor type 3 antibody
        • CC CKR 3 antibody
        • CC R3 antibody
        • CC-CKR-3 antibody
        • CCCKR3 antibody
        • CCR 3 antibody
        • CCR-3 antibody
        • CCR3 antibody
        • CCR3_HUMAN antibody
        • CD 193 antibody
        • CD193 antibody
        • CD193 antigen antibody
        • Chemokine (C C motif) receptor 3 antibody
        • chemokine (C-C motif) receptor 3 antibody
        • Chemokine (CC) receptor 1 like 2 antibody
        • Chemokine CC motif receptor 3 antibody
        • Chemokine receptor 3 antibody
        • CK R3 antibody
        • CKR 3 antibody
        • CKR3 antibody
        • CMKB R3 antibody
        • CMKBR 3 antibody
        • CMKBR1L2 antibody
        • CMKBR3 antibody
        • Eosinophil CC chemokine receptor 3 antibody
        • Eosinophil eotaxin receptor antibody
        • Eotaxin receptor antibody
        • Macrophage inflammatory protein 1 alpha receptor like 2 antibody
        • MGC102841 antibody
        • MIP1 Alpha RL2 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR3 antibody (ab25789)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR3 antibody (ab25789)
        Immunohistochemistry of CCR3 (ab25789) antibody to mouse CCR3 on paraffin section of mouse spleen.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab25789? Please let us know so that we can cite the reference in this datasheet.

      ab25789 has not yet been referenced specifically in any publications.

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