Overview

  • Product name
    Anti-CCR6 antibody
    See all CCR6 primary antibodies
  • Description
    Goat polyclonal to CCR6
  • Host species
    Goat
  • Tested applications
    Suitable for: IHC-Fr, ELISA, ICC, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse
  • Immunogen

    Synthetic peptide:

    YFVSVNTSYYSVDSEMLLCSLQEVRQFSR

    , corresponding to amino acids 18-46 of Human CCR6.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Human spleen or peripheral blood

Properties

Applications

Our Abpromise guarantee covers the use of ab1659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/250. PubMed: 19095953
ELISA 1/75000.
ICC 1/300.
IHC-P 1/250.

Target

  • Function
    Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.
  • Tissue specificity
    Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
    • Alternative names
      • BN 1 antibody
      • BN1 antibody
      • C C chemokine receptor type 6 antibody
      • C C CKR 6 antibody
      • C-C chemokine receptor type 6 antibody
      • C-C CKR-6 antibody
      • CC chemokine receptor type 6 antibody
      • CC CKR 6 antibody
      • CC R6 antibody
      • CC-CKR-6 antibody
      • CCCKR6 antibody
      • CCR 6 antibody
      • CCR-6 antibody
      • Ccr6 antibody
      • CCR6_HUMAN antibody
      • CD 196 antibody
      • CD196 antibody
      • CD196 antigen antibody
      • Chemokine (C C motif) receptor 6 antibody
      • Chemokine (C C) receptor 6 antibody
      • Chemokine (CC motif) receptor 6 antibody
      • Chemokine (CC) receptor 6 antibody
      • Chemokine receptor 6 antibody
      • Chemokine receptor like 3 antibody
      • Chemokine receptor-like 3 antibody
      • CKR 6 antibody
      • CKR L3 antibody
      • CKR-L3 antibody
      • CKR6 antibody
      • CKRL3 antibody
      • CMKBR 6 antibody
      • CMKBR6 antibody
      • DCR 2 antibody
      • DCR2 antibody
      • DRY 6 antibody
      • DRY6 antibody
      • G protein coupled receptor 29 antibody
      • G-protein coupled receptor 29 antibody
      • GPR 29 antibody
      • GPR CY4 antibody
      • GPR-CY4 antibody
      • GPR29 antibody
      • GPRCY 4 antibody
      • GPRCY4 antibody
      • LARC receptor antibody
      • Seven transmembrane receptor lymphocyte 22 antibody
      • STRL 22 antibody
      • STRL22 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR6 antibody (ab1659)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR6 antibody (ab1659)
      Immunohistochemistry on paraffin section of human spleen, at 1/250 dilution.

    References

    This product has been referenced in:
    • Salim SY  et al. CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease. Am J Pathol 174:82-90 (2009). IHC-Fr ; Human . Read more (PubMed: 19095953) »

    See 1 Publication for this product

    Publishing research using ab1659? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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    3 reviews or Q&A

    10
    Votes: Highest First

    Please recommend a negative control for this antibody.

    I was informed that the best negative control is affinity purified goat IgG antibody to a protein that is not expressed on the target cells cells/tissues to be examined. For example affinity purified Goat IgG antibody to Trail-2 or Trail-3 receptor ant...

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    What is the molecular weight of this ab?

    Thank you for your enquiry. The molecular weight of this antibody is 425kDa. Please contact us again if you require further information.

    I have recently purchased this antibody from you based on your information sheet. It states that the antibody cross reacts with mouse CCR6. My Western was negative, so I looked into why this could be. I referred to the paper you cited as using the an...

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    The source of ab1659 has replied to me the following: "We agree with the customer that antibody to human CCR6 should not react with the mouse CCR6 because of the significant sequence differences. However, work with mouse white bloods cells showed c...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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