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    ccr6-antibody-ab1659.pdf

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Immunology Innate Immunity Chemokines Beta Chemokine Rec. (CCR)
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Anti-CCR6 antibody (ab1659)

  • Datasheet
  • SDS
Submit a review Q&A (3)References (1)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR6 antibody (ab1659)

    Key features and details

    • Goat polyclonal to CCR6
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)

    View more associated products

    Overview

    • Product name

      Anti-CCR6 antibody
      See all CCR6 primary antibodies
    • Description

      Goat polyclonal to CCR6
    • Host species

      Goat
    • Tested Applications & Species

      Application Species
      IHC-P
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide:

      YFVSVNTSYYSVDSEMLLCSLQEVRQFSR

      , corresponding to amino acids 18-46 of Human CCR6.
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    • Storage buffer

      Preservative: 0.1% Sodium azide
      Constituent: 0.1% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Immunology
      • Innate Immunity
      • Chemokines
      • Beta Chemokine Rec. (CCR)
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Cardiovascular
      • Angiogenesis
      • Endothelial Cell Markers

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab1659 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Human
    Application Abreviews Notes
    IHC-P
    1/250.
    Notes
    IHC-P
    1/250.

    Target

    • Function

      Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.
    • Tissue specificity

      Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession P51684 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 1235 Human
      • Omim: 601835 Human
      • SwissProt: P51684 Human
      • Unigene: 46468 Human
      • Alternative names

        • BN 1 antibody
        • BN1 antibody
        • C C chemokine receptor type 6 antibody
        • C C CKR 6 antibody
        • C-C chemokine receptor type 6 antibody
        • C-C CKR-6 antibody
        • CC chemokine receptor type 6 antibody
        • CC CKR 6 antibody
        • CC R6 antibody
        • CC-CKR-6 antibody
        • CCCKR6 antibody
        • CCR 6 antibody
        • CCR-6 antibody
        • Ccr6 antibody
        • CCR6_HUMAN antibody
        • CD 196 antibody
        • CD196 antibody
        • CD196 antigen antibody
        • Chemokine (C C motif) receptor 6 antibody
        • Chemokine (C C) receptor 6 antibody
        • Chemokine (CC motif) receptor 6 antibody
        • Chemokine (CC) receptor 6 antibody
        • Chemokine receptor 6 antibody
        • Chemokine receptor like 3 antibody
        • Chemokine receptor-like 3 antibody
        • CKR 6 antibody
        • CKR L3 antibody
        • CKR-L3 antibody
        • CKR6 antibody
        • CKRL3 antibody
        • CMKBR 6 antibody
        • CMKBR6 antibody
        • DCR 2 antibody
        • DCR2 antibody
        • DRY 6 antibody
        • DRY6 antibody
        • G protein coupled receptor 29 antibody
        • G-protein coupled receptor 29 antibody
        • GPR 29 antibody
        • GPR CY4 antibody
        • GPR-CY4 antibody
        • GPR29 antibody
        • GPRCY 4 antibody
        • GPRCY4 antibody
        • LARC receptor antibody
        • Seven transmembrane receptor lymphocyte 22 antibody
        • STRL 22 antibody
        • STRL22 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR6 antibody (ab1659)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR6 antibody (ab1659)
        Immunohistochemistry on paraffin section of human spleen, at 1/250 dilution.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (1)

      Publishing research using ab1659? Please let us know so that we can cite the reference in this datasheet.

      ab1659 has been referenced in 1 publication.

      • Salim SY  et al. CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease. Am J Pathol 174:82-90 (2009). IHC-Fr ; Human . PubMed: 19095953

      Customer reviews and Q&As

      Show All Reviews Q&A
      Submit a review Submit a question

      1-3 of 3 Abreviews or Q&A

      Question

      Please recommend a negative control for this antibody.

      Read More

      Abcam community

      Verified customer

      Asked on Aug 30 2006

      Answer

      I was informed that the best negative control is affinity purified goat IgG antibody to a protein that is not expressed on the target cells cells/tissues to be examined. For example affinity purified Goat IgG antibody to Trail-2 or Trail-3 receptor antibody will be a good negative control. In our studies these antibodies failed to stain lymphoid cells. Other similar antigen-affinity purified goat IgG antibodies can also be used as negative controls. I hope this information will be useful,

      Read More

      Abcam Scientific Support

      Answered on Sep 04 2006

      Question

      What is the molecular weight of this ab?

      Read More

      Abcam community

      Verified customer

      Asked on Apr 07 2005

      Answer

      Thank you for your enquiry. The molecular weight of this antibody is 425kDa. Please contact us again if you require further information.

      Read More

      Abcam Scientific Support

      Answered on Apr 07 2005

      Question

      I have recently purchased this antibody from you based on your information sheet. It states that the antibody cross reacts with mouse CCR6. My Western was negative, so I looked into why this could be. I referred to the paper you cited as using the antibody, but was unable to find any reference to it in the paper (GPR-CY4 = CCR6). Secondly the homology between the Human immunogen and the mouse peptide sequence is less than 50%. Your data sheet indicates that the product has been tested in mouse and Human. I would be very grateful if you could send me data regarding the western blotting of your antibody to mouse CCR6.

      Read More

      Abcam community

      Verified customer

      Asked on Nov 11 2004

      Answer

      The source of ab1659 has replied to me the following: "We agree with the customer that antibody to human CCR6 should not react with the mouse CCR6 because of the significant sequence differences. However, work with mouse white bloods cells showed clearly positive blot results. At the present time we are looking at that data with more scrutiny. From now on the datasheets should be modified recommending that the antibody should be sold only for human CCR6 receptor only. We know that the extracellular domain of CCR6 does not extend up to amino acid 46 but due to glycosylation sites at the amino terminus of the extracellular domain of human CCR6. We chose to include additional residues at the C-terminal end of the peptide due to scientific and technical reasons that are confidential." Following this correspondence we have decided to change our datasheet to reflect your findings and those of the originator. I would like to offer you our sincere apologies for this problem and arrange a refund to be sent to you. Could you please let me know the Abcam order number and/or PO number and name of the person who placed the order and I will arrange this immediately. I'm very sorry for the inconvenience and look forward to hearing from you,

      Read More

      Abcam Scientific Support

      Answered on Nov 22 2004

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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