Anti-CCR7 antibody (ab191575)
Key features and details
- Rabbit polyclonal to CCR7
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CCR7 antibody
See all CCR7 primary antibodies -
Description
Rabbit polyclonal to CCR7 -
Host species
Rabbit -
Specificity
ab191575 is predicted to not cross-react with other CCR proteins. -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human CCR7 (internal sequence). (15 amino acid peptide; NP_001829).
Database link: P32248 -
Positive control
- Human spleen tissue lysate; Human spleen tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab191575 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 - 20 µg/ml.
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 43 kDa.
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Notes |
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IHC-P
Use a concentration of 5 - 20 µg/ml. |
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 43 kDa. |
Target
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Function
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. -
Tissue specificity
Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 1236 Human
- Omim: 600242 Human
- SwissProt: P32248 Human
- Unigene: 370036 Human
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Alternative names
- BLR 2 antibody
- BLR2 antibody
- C C chemokine receptor type 7 antibody
see all
Images
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Immunohistochemical analysis of paraffin-embedded Human spleen tissue labeling CCR7 with ab191575 at 5 µg/ml.
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Anti-CCR7 antibody (ab191575) at 1 µg/ml + Human spleen tissue lysate at 15 µg
Predicted band size: 43 kDa -
Immunohistochemical analysis of paraffin-embedded Human spleen tissue labeling CCR7 with ab191575 at 20 µg/ml.
Protocols
Datasheets and documents
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Datasheet download
References (5)
ab191575 has been referenced in 5 publications.
- Chen J et al. VX-765 reduces neuroinflammation after spinal cord injury in mice. Neural Regen Res 16:1836-1847 (2021). PubMed: 33510091
- Chen YQ et al. CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment. J Neuroinflammation 17:255 (2020). PubMed: 32861243
- Chen S et al. Eluted 25-hydroxyvitamin D3 from radially aligned nanofiber scaffolds enhances cathelicidin production while reducing inflammatory response in human immune system-engrafted mice. Acta Biomater 97:187-199 (2019). PubMed: 31386930
- Zhao Y et al. The effects of CCR7 and related signaling pathways on Leishmania major -infected human dendritic cells. J Cell Physiol N/A:N/A (2018). PubMed: 30584667
- van Dijk RA et al. A change in inflammatory footprint precedes plaque instability: a systematic evaluation of cellular aspects of the adaptive immune response in human atherosclerosis. J Am Heart Assoc 4:N/A (2015). IHC-P ; Human . PubMed: 25814626