Key features and details
- Mouse monoclonal [1B2] to CCRL2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG2a
Product nameAnti-CCRL2 antibody [1B2]
See all CCRL2 primary antibodies
DescriptionMouse monoclonal [1B2] to CCRL2
SpecificityThe specificity of ab167114 was verified by flow cytometry with cells expressing the recombinant protein.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Other Immunogen Type corresponding to Human CCRL2.
Database link: O00421
- Human placenta tissue.
This product was previously labelled as CCRL2
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.20
Preservative: 0.1% KATHON™ CG/ICP
Constituents: 99% PBS, 0.5% BSA
Concentration information loading...
PurityProtein G purified
Light chain typekappa
Our Abpromise guarantee covers the use of ab167114 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 4 - 8 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.|
FunctionReceptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Tissue specificityExpressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
DomainLacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
Cellular localizationCell membrane.
- Information by UniProt
- C-C chemokine receptor-like 2 antibody
- CCRL2 antibody
- CCRL2_HUMAN antibody
ab167114 has been referenced in 1 publication.
- Reyes N et al. Atypical chemokine receptor CCRL2 is overexpressed in prostate cancer cells. J Biomed Res N/A:N/A (2017). PubMed: 29497024