Key features and details
- Selective, cell-permeable Hsp90 ATPase inhibitor
- CAS Number: 171009-07-7
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameCCT 018159, Hsp90 ATPase inhibitor
DescriptionSelective, cell-permeable Hsp90 ATPase inhibitor
Selective, cell-permeable Hsp90 ATPase inhibitor (IC50 values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1/DT-diaphorase and P-glycoprotein expression.
Storage instructionsShipped at 4°C. Store at +4°C.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 100 mM
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146412 has not yet been referenced specifically in any publications.