CCT 018159, Hsp90 ATPase inhibitor (ab146412)

Overview

  • Product name

    CCT 018159, Hsp90 ATPase inhibitor
  • Description

    Selective, cell-permeable Hsp90 ATPase inhibitor
  • Biological description

    Selective, cell-permeable Hsp90 ATPase inhibitor (IC50 values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1/DT-diaphorase and P-glycoprotein expression. 

  • Purity

    > 98%
  • CAS Number

    171009-07-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
  • Molecular weight

    352.39
  • Molecular formula

    C20H20N2O4
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCc1cc(c(cc1O)O)c2c(c([nH]n2)C)c3ccc4c(c3)OCCO4
  • Source

    Synthetic

References

This product has been referenced in:

  • Sugiyama A  et al. Inhibition of heat shock protein 90 decreases ACTH production and cell proliferation in AtT-20 cells. Pituitary 18:542-53 (2015). Read more (PubMed: 25280813) »
  • van der Kraan AG  et al. HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors. Biochem J 451:235-44 (2013). Read more (PubMed: 23379601) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146412.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up