Overview

  • Product name

    CD 437, RARgamma-selective agonist.
  • Description

    Potent, cell-permeable RARγ-selective agonist.
  • Biological description

    Potent, cell-permeable RARγ-selective agonist (EC50 values are 140, 28 and 7 nM for RAR-α, β and γ respectively). Shows RARγ-dependent and -independent effects on differentiation and apoptosis. Shows antitumor effects in vivo.
  • Purity

    > 99%
  • CAS Number

    125316-60-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
  • Molecular weight

    398.50
  • Molecular formula

    C27H26O3
  • PubChem identifier

    135411
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)c1ccc2cc(ccc2c1)c6cc(C5C3CC4CC5CC(C3)C4)c(O)cc6
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mukhopadhyay B  et al. Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. J Biol Chem 285:19002-11 (2010). Read more (PubMed: 20410309) »
  • Schneider SM  et al. Activation of retinoic acid receptor alpha is sufficient for full induction of retinoid responses in SK-BR-3 and T47D human breast cancer cells. Cancer Res 60:5479-87 (2000). Read more (PubMed: 11034091) »
  • Langdon SP  et al. Growth-inhibitory effects of the synthetic retinoid CD437 against ovarian carcinoma models in vitro and in vivo. Cancer Chemother Pharmacol 42:429-32 (1998). Read more (PubMed: 9771960) »
  • Zhao X & Spanjaard RA The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J Biomed Sci 10:44-9 (0). Read more (PubMed: 12566985) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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