Product nameAnti-CD105 antibody
See all CD105 primary antibodies
DescriptionRabbit polyclonal to CD105
Tested applicationsSuitable for: ELISA, WB, Flow Cytmore details
Species reactivityReacts with: Mouse
Highly pure recombinant mouse soluble CD105 (aas 26-581) bearing His 6 C-terminal tag.
FormLyophilised:The lyophilized IgG is stable at 4°C for at least six months and for greater than a year when kept at –20°C. When reconstituted in sterile water/PBS to a concentration of >0.5 mg/ml the antibody is stable for at least six weeks at 2-4°C. Avoid repeated freeze-thaw cycles.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: None
Constituents: PBS, pH 7.4
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab21222 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use a concentration of 1 - 15 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 71 kDa.|
|Flow Cyt||Use at an assay dependent concentration. PubMed: 23894503
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
FunctionMajor glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Tissue specificityEndoglin is restricted to endothelial cells in all tissues except bone marrow.
Involvement in diseaseDefects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
- Information by UniProt
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This product has been referenced in:
- Tingling JD et al. CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models. PLoS One 8:e69560 (2013). Flow Cyt ; Mouse . Read more (PubMed: 23894503) »