Anti-CD116 antibody [4H1] (ab95681)

Submit a review Submit a question
Flow Cytometry - Anti-CD116 antibody [4H1] (ab95681)

    Key features and details

    • Mouse monoclonal [4H1] to CD116
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Isotype: IgG1

    Overview

    • Product name

      Anti-CD116 antibody [4H1]
      See all CD116 primary antibodies

    • Description

      Mouse monoclonal [4H1] to CD116

    • Host species

      Mouse

    • Tested applications

      Suitable for: Flow Cytmore details

    • Species reactivity

      Reacts with: Human

    • Immunogen

      Tissue, cells or virus corresponding to Human CD116.

    • Positive control

      • Human peripheral blood leukocytes

    • General notes

       This product was previously labelled as GM-CSF Receptor alpha

       

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab95681 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Flow Cyt
    Use at an assay dependent concentration.

    Use primary antibody at 1 µg/test.
    Notes
    Flow Cyt
    Use at an assay dependent concentration.

    Use primary antibody at 1 µg/test.

    Target

    • Function

      Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

    • Involvement in disease

      Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

    • Sequence similarities

      Belongs to the type I cytokine receptor family. Type 5 subfamily.

    • Domain

      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.

    • Cellular localization

      Secreted and Cell membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • CD_antigen=CD116 antibody
        • CD116 antibody
        • CD116 antigen antibody
        • CDw116 antibody
        • Colony stimulating factor 2 receptor alpha chain antibody
        • Colony stimulating factor 2 receptor alpha low affinity antibody
        • Colony stimulating factor 2 receptor alpha subunit antibody
        • CSF 2R antibody
        • CSF2R antibody
        • CSF2R_HUMAN antibody
        • CSF2RA antibody
        • CSF2RAX antibody
        • CSF2RAY antibody
        • CSF2RX antibody
        • CSF2RY antibody
        • GM CSF R alpha antibody
        • GM CSF receptor alpha subunit antibody
        • GM-CSF-R-alpha antibody
        • GMCSFR antibody
        • GMCSFR-alpha antibody
        • GMR-alpha antibody
        • Granulocyte macrophage colony stimulating factor receptor alpha chain antibody
        • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody
        • SMDP4 antibody
        see all

      Images

      • Flow Cytometry - Anti-CD116 antibody [4H1] (ab95681)
        Flow Cytometry - Anti-CD116 antibody [4H1] (ab95681)

        Flow cytometry analysis of normal human peripheral blood cells labeling CD116 with ab95681 at 1 µg/test. Anti-CD116 FITC (left) and PE (right). Appropriate isotype controls were used (open histogram). Cells in the monocyte population were used for analysis.

      References (0)

      Publishing research using ab95681? Please let us know so that we can cite the reference in this datasheet.

      ab95681 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

      Show All Reviews Q&A
      Submit a review Submit a question

      There are currently no Customer reviews or Questions for ab95681.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com