Anti-CD116 antibody [4H1] (ab95681)
![Flow Cytometry - Anti-CD116 antibody [4H1] (ab95681)](https://www.abcam.com/ps/products/95/ab95681/Images/ab95681-464407-anti-cd116-antibody-4h1-flow-cytometry-blood-monocyte-human.jpg "Flow Cytometry - Anti-CD116 antibody [4H1] (ab95681)")
Key features and details
- Mouse monoclonal [4H1] to CD116
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
Related conjugates and formulations
Overview
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Product name
Anti-CD116 antibody [4H1]
See all CD116 primary antibodies -
Description
Mouse monoclonal [4H1] to CD116 -
Host species
Mouse -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human CD116. CD116-transfected COS cells.
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Positive control
- Human peripheral blood leukocytes
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.87% Sodium chloride, PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
4H1 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab95681 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
Use primary antibody at 1 µg/test. |
| Notes |
|---|
|
Flow Cyt
Use at an assay dependent concentration. Use primary antibody at 1 µg/test. |
Target
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Function
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. -
Involvement in disease
Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. -
Sequence similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily. -
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 1438 Human
- Omim: 306250 Human
- SwissProt: P15509 Human
- Unigene: 520937 Human
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Alternative names
- CD_antigen=CD116 antibody
- CD116 antibody
- CD116 antigen antibody
see all
Images
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Flow Cytometry - Anti-CD116 antibody [4H1] (ab95681)
Flow cytometry analysis of normal human peripheral blood cells labeling CD116 with ab95681 at 1 µg/test. Anti-CD116 FITC (left) and PE (right). Appropriate isotype controls were used (open histogram). Cells in the monocyte population were used for analysis.
Datasheets and documents
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Datasheet download
References (0)
ab95681 has not yet been referenced specifically in any publications.
