Overview

  • Product name

    Anti-CD116 antibody [4H1] (Phycoerythrin)
    See all CD116 primary antibodies
  • Description

    Mouse monoclonal [4H1] to CD116 (Phycoerythrin)
  • Host species

    Mouse
  • Conjugation

    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human CD116.

  • Positive control

    • Normal human peripheral blood cells/leukocytes.
  • General notes

     This product was previously labelled as GM-CSF Receptor alpha

     

Properties

Applications

Our Abpromise guarantee covers the use of ab95683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 5µl for 106 cells.

Target

  • Function

    Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
  • Involvement in disease

    Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD_antigen=CD116 antibody
    • CD116 antibody
    • CD116 antigen antibody
    • CDw116 antibody
    • Colony stimulating factor 2 receptor alpha chain antibody
    • Colony stimulating factor 2 receptor alpha low affinity antibody
    • Colony stimulating factor 2 receptor alpha subunit antibody
    • CSF 2R antibody
    • CSF2R antibody
    • CSF2R_HUMAN antibody
    • CSF2RA antibody
    • CSF2RAX antibody
    • CSF2RAY antibody
    • CSF2RX antibody
    • CSF2RY antibody
    • GM CSF R alpha antibody
    • GM CSF receptor alpha subunit antibody
    • GM-CSF-R-alpha antibody
    • GMCSFR antibody
    • GMCSFR-alpha antibody
    • GMR-alpha antibody
    • Granulocyte macrophage colony stimulating factor receptor alpha chain antibody
    • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody
    • SMDP4 antibody
    see all

Images

  • Flow cytometry staining of normal Human peripheral blood cells with Mouse IgG1 ? Isotype Control PE (open histogram) or 20µl ab95683 (filled histogram). Cells in the monocyte gate were used for analysis.

References

ab95683 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab95683.
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