Overview

  • Product name

  • Description

    Rabbit polyclonal to CD116
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Mouse CD116 aa 110-155 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    G GAAAHWRLSF VNEGAAGSGA ENLTCEIRAA RFLSCAWREG PAAPA


    Database link: Q00941

  • Positive control

    • Mouse intestine tissue and Myeloma cells.
  • General notes

     This product was previously labelled as GM-CSF Receptor alpha

     

Properties

Applications

Our Abpromise guarantee covers the use of ab202851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Use at 1/50 - 1/200 with fluorescent detection methods.

WB 1/100 - 1/1000. Predicted molecular weight: 42 kDa.

Target

  • Function

    Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
  • Involvement in disease

    Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD_antigen=CD116 antibody
    • CD116 antibody
    • CD116 antigen antibody
    • CDw116 antibody
    • Colony stimulating factor 2 receptor alpha chain antibody
    • Colony stimulating factor 2 receptor alpha low affinity antibody
    • Colony stimulating factor 2 receptor alpha subunit antibody
    • CSF 2R antibody
    • CSF2R antibody
    • CSF2R_HUMAN antibody
    • CSF2RA antibody
    • CSF2RAX antibody
    • CSF2RAY antibody
    • CSF2RX antibody
    • CSF2RY antibody
    • GM CSF R alpha antibody
    • GM CSF receptor alpha subunit antibody
    • GM-CSF-R-alpha antibody
    • GMCSFR antibody
    • GMCSFR-alpha antibody
    • GMR-alpha antibody
    • Granulocyte macrophage colony stimulating factor receptor alpha chain antibody
    • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody
    • SMDP4 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded mouse intestine tissue labeling CD116 with ab202851 at 1/200, overnight at 4°C. The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated at 1/200 dilution.

  • Immunofluorescent analysis of Myeloma cells labeling CD116 with ab202851 at 1/50 dilution. Nuclear staining obtained using DAPI.

References

ab202851 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab202851.
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