Overview

  • Product name

    Anti-CD116 antibody [EPR8808]
    See all CD116 primary antibodies
  • Description

    Rabbit monoclonal [EPR8808] to CD116
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CD116 aa 1-100.
    Database link: P15509

  • Positive control

    • 293T, THP1, HepG2 and Human placenta lysates
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

     This product was previously labelled as GM-CSF Receptor alpha

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab133678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 46 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
    • Involvement in disease

      Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
    • Sequence similarities

      Belongs to the type I cytokine receptor family. Type 5 subfamily.
    • Domain

      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.
    • Cellular localization

      Secreted and Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • CD_antigen=CD116 antibody
      • CD116 antibody
      • CD116 antigen antibody
      • CDw116 antibody
      • Colony stimulating factor 2 receptor alpha chain antibody
      • Colony stimulating factor 2 receptor alpha low affinity antibody
      • Colony stimulating factor 2 receptor alpha subunit antibody
      • CSF 2R antibody
      • CSF2R antibody
      • CSF2R_HUMAN antibody
      • CSF2RA antibody
      • CSF2RAX antibody
      • CSF2RAY antibody
      • CSF2RX antibody
      • CSF2RY antibody
      • GM CSF R alpha antibody
      • GM CSF receptor alpha subunit antibody
      • GM-CSF-R-alpha antibody
      • GMCSFR antibody
      • GMCSFR-alpha antibody
      • GMR-alpha antibody
      • Granulocyte macrophage colony stimulating factor receptor alpha chain antibody
      • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody
      • SMDP4 antibody
      see all

    Images

    • All lanes : Anti-CD116 antibody [EPR8808] (ab133678) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : THP1 cell lysate
      Lane 3 : HepG2 cell lysate
      Lane 4 : Human placenta lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

      Predicted band size: 46 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab133678 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab133678.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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