Key features and details
- Rat monoclonal [M17/4] to CD11a
- Suitable for: IP, IHC-Fr, Functional Studies, Flow Cyt, Blocking
- Reacts with: Mouse
- Isotype: IgG2a
Product nameAnti-CD11a antibody [M17/4]
See all CD11a primary antibodies
DescriptionRat monoclonal [M17/4] to CD11a
Tested applicationsSuitable for: IP, IHC-Fr, Functional Studies, Flow Cyt, Blockingmore details
Species reactivityReacts with: Mouse
C57BL/6 Mouse splenic secondary cytotoxic T lymphocytes.
- Mouse spleen or thymus tissues
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted.
Storage bufferpH: 7.40
Preservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab119878 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration.|
|IHC-Fr||Use at an assay dependent concentration. Application note: acetone fixation|
|Functional Studies||Use at an assay dependent concentration.|
|Flow Cyt||Use a concentration of 1 µg/ml.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
|Blocking||Use at an assay dependent concentration.|
FunctionIntegrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Sequence similaritiesBelongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Information by UniProt
- Lymphocyte function associated antigen, type 1, alpha subunit antibody
- Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
- Antigen CD11A antibody
ab119878 has been referenced in 4 publications.
- Angelov GS et al. Soluble MHC-peptide complexes containing long rigid linkers abolish CTL-mediated cytotoxicity. J Immunol 176:3356-65 (2006). PubMed: 16517703
- Beyer M et al. The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. Respir Res 6:70 (2005). PubMed: 16011799
- Bellingan GJ et al. Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J Exp Med 196:1515-21 (2002). PubMed: 12461086
- Papayannopoulou T et al. Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice. Blood 97:1282-8 (2001). PubMed: 11222371