Key features and details
- Mouse monoclonal [BU15] to CD11c (FITC)
- Reacts with: Dog, Human, Cynomolgus monkey
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Product nameAnti-CD11c antibody [BU15] (FITC)
See all CD11c primary antibodies
DescriptionMouse monoclonal [BU15] to CD11c (FITC)
ConjugationFITC. Ex: 493nm, Em: 528nm
SpecificityThis antibody recognises the integrin alphax subunit, a 150kD glycoprotein expressed by macrophages, monocytes, granulocytes and NK cells. The antigen is also expressed by hairy cell leukaemia cells. Ligands for CD11c are ICAM 1, iC3b, and fibrinogen. The molecule has a role in mediating adherence of granulocytes and monocytes to endothelium and fibrinogen.
Species reactivityReacts with: Dog, Human, Cynomolgus monkey
The details of the immunogen for this antibody are not available.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: 1% BSA
Concentration information loading...
PurityProtein G purified
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionIntegrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Tissue specificityPredominantly expressed in monocytes and granulocytes.
Sequence similaritiesBelongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Information by UniProt
- 95 alpha chain antibody
- 95 antibody
- CD 11c antibody
ab22540 has been referenced in 3 publications.
- Langer S et al. HIV-1 Vpu is a potent transcriptional suppressor of NF-?B-elicited antiviral immune responses. Elife 8:N/A (2019). PubMed: 30717826
- Braun E et al. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Rep 27:2092-2104.e10 (2019). PubMed: 31091448
- Rezzonico R et al. Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood 97:2932-40 (2001). PubMed: 11342414