Anti-CD11+CD18 antibody [24] (ab13219)
Key features and details
- Mouse monoclonal [24] to CD11+CD18
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-CD11+CD18 antibody [24]
See all CD11+CD18 primary antibodies -
Description
Mouse monoclonal [24] to CD11+CD18 -
Host species
Mouse -
Specificity
This antibody specifically recognises the human CD11+CD18 activation epitope. -
Species reactivity
Reacts with: Human -
Immunogen
Fibronectin-purified human monocytes.
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Epitope
Recognises an epitope which is expressed by beta 2 (CD18) integrins in high affinity conformation.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein A/G purified -
Clonality
Monoclonal -
Clone number
24 -
Myeloma
Sp2/0-Ag14 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Isotype control
Target
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Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. -
Tissue specificity
Leukocytes. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3683 Human
- Entrez Gene: 3684 Human
- Entrez Gene: 3687 Human
- Entrez Gene: 3689 Human
- Omim: 120980 Human
- Omim: 600065 Human
- SwissProt: P05107 Human
- SwissProt: P11215 Human
see all -
Alternative names
- Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
- CD11 antigen-like family member A antibody
- CD11a antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (16)
ab13219 has been referenced in 16 publications.
- Chen Q et al. Leukocyte-mimicking Pluronic-lipid nanovesicle hybrids inhibit the growth and metastasis of breast cancer. Nanoscale 11:5377-5394 (2019). PubMed: 30849160
- Drewry LL et al. The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration. Nat Microbiol 4:1951-1963 (2019). PubMed: 31332383
- Yuan X et al. Recipient treatment with acetylcholinesterase inhibitor donepezil attenuates primary graft failure in rats through inhibiting post-transplantational donor heart ischaemia/reperfusion injury. Eur J Cardiothorac Surg 53:400-408 (2018). PubMed: 28950359
- Laufer JM et al. CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70. Front Immunol 9:3115 (2018). PubMed: 30692994
- Manwani D et al. Single-dose intravenous gammaglobulin can stabilize neutrophil Mac-1 activation in sickle cell pain crisis. Am J Hematol 90:381-5 (2015). Flow Cyt ; Human . PubMed: 25616042