Anti-CD11+CD18 antibody [24] (ab13219)
Key features and details
- Mouse monoclonal [24] to CD11+CD18
- Suitable for: IP, RIA, ICC/IF, WB, Flow Cyt
- Reacts with: Mouse, Rat, Dog, Human
- Isotype: IgG1
Related conjugates and formulations
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-CD11+CD18 antibody [24]
See all CD11+CD18 primary antibodies -
Description
Mouse monoclonal [24] to CD11+CD18 -
Host species
Mouse -
Specificity
This antibody specifically recognises the human CD11+CD18 activation epitope. -
Tested applications
Suitable for: IP, RIA, ICC/IF, WB, Flow Cytmore details -
Species reactivity
Reacts with: Mouse, Rat, Dog, Human -
Immunogen
Tissue, cells or virus corresponding to Human CD11+CD18. Fibronectin-purified human monocytes.
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Epitope
Recognises an epitope which is expressed by beta 2 (CD18) integrins in high affinity conformation. -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: PBS -
Concentration information loading... -
Purity
Protein A/G purified -
Clonality
Monoclonal -
Clone number
24 -
Myeloma
Sp2/0-Ag14 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab13219 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IP |
Use at an assay dependent concentration.
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| RIA |
Use at an assay dependent concentration.
|
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| ICC/IF |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration. Predicted molecular weight: 129 kDa. PubMed: 22473604
|
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| Flow Cyt | (5) |
Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| Notes |
|---|
|
IP
Use at an assay dependent concentration. |
|
RIA
Use at an assay dependent concentration. |
|
ICC/IF
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 129 kDa. PubMed: 22473604 |
|
Flow Cyt
Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Target
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Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. -
Tissue specificity
Leukocytes. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3683 Human
- Entrez Gene: 3684 Human
- Entrez Gene: 3687 Human
- Entrez Gene: 3689 Human
- Entrez Gene: 16408 Mouse
- Entrez Gene: 16409 Mouse
- Entrez Gene: 16414 Mouse
- Entrez Gene: 25021 Rat
see all -
Alternative names
- Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
- CD11 antigen-like family member A antibody
- CD11a antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (19)
ab13219 has been referenced in 19 publications.
- Cao JY et al. Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics 11:5248-5266 (2021). PubMed: 33859745
- Liu Y et al. Pseudoginsenoside-F11 Accelerates Microglial Phagocytosis of Myelin Debris and Attenuates Cerebral Ischemic Injury Through Complement Receptor 3. Neuroscience 426:33-49 (2020). PubMed: 31790669
- Chen RH et al. Tumor Cell-Secreted ISG15 Promotes Tumor Cell Migration and Immune Suppression by Inducing the Macrophage M2-Like Phenotype. Front Immunol 11:594775 (2020). PubMed: 33424843
- Chen Q et al. Leukocyte-mimicking Pluronic-lipid nanovesicle hybrids inhibit the growth and metastasis of breast cancer. Nanoscale 11:5377-5394 (2019). PubMed: 30849160
- Drewry LL et al. The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration. Nat Microbiol 4:1951-1963 (2019). PubMed: 31332383