Anti-CD130 (gp130) antibody [B-R3] (ab34315)

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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab34315 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 
WB Use at an assay dependent concentration. Predicted molecular weight: 103 kDa.
IP Use at an assay dependent concentration.

Target

  • Function

    Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

  • Tissue specificity

    Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

  • Post-translational
    modifications

    Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD130 antibody
      • CD130 antigen antibody
      • CDw130 antibody
      • gp130 antibody
      • GP130 RAPS antibody
      • IL 6R beta antibody
      • IL-6 receptor subunit beta antibody
      • IL-6R subunit beta antibody
      • IL-6R-beta antibody
      • IL-6RB antibody
      • IL6 ST antibody
      • IL6RB_HUMAN antibody
      • IL6ST antibody
      • Interleukin 6 receptor subunit beta antibody
      • Interleukin receptor beta chain antibody
      • Interleukin-6 receptor subunit beta antibody
      • Interleukin-6 signal transducer antibody
      • Membrane glycoprotein 130 antibody
      • Membrane glycoprotein gp130 antibody
      • Oncostatin M receptor antibody
      • Oncostatin M receptor alpha subunit antibody
      • Oncostatin-M receptor subunit alpha antibody
      see all

    References

    This product has been referenced in:

    • Lamertz L  et al. Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130. Cytokine N/A:N/A (2018). Read more (PubMed: 29789201) »
    • Wijdenes J  et al. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Eur J Immunol 25:3474-81 (1995). Read more (PubMed: 8566040) »
    See all 2 Publications for this product

    Publishing research using ab34315? Please let us know so that we can cite the reference in this datasheet.

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