Anti-CD130 (gp130) antibody [B-R3] (ab34315)

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Key features and details

  • Mouse monoclonal [B-R3] to CD130 (gp130)
  • Suitable for: Flow Cyt, WB, IP
  • Reacts with: Human
  • Isotype: IgG2a

Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab34315 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 
WB Use at an assay dependent concentration. Predicted molecular weight: 103 kDa.
IP Use at an assay dependent concentration.

Target

  • Function

    Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

  • Tissue specificity

    Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

  • Post-translational
    modifications

    Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • CD130 antibody
      • CD130 antigen antibody
      • CDw130 antibody
      • gp130 antibody
      • GP130 RAPS antibody
      • IL 6R beta antibody
      • IL-6 receptor subunit beta antibody
      • IL-6R subunit beta antibody
      • IL-6R-beta antibody
      • IL-6RB antibody
      • IL6 ST antibody
      • IL6RB_HUMAN antibody
      • IL6ST antibody
      • Interleukin 6 receptor subunit beta antibody
      • Interleukin receptor beta chain antibody
      • Interleukin-6 receptor subunit beta antibody
      • Interleukin-6 signal transducer antibody
      • Membrane glycoprotein 130 antibody
      • Membrane glycoprotein gp130 antibody
      • Oncostatin M receptor antibody
      • Oncostatin M receptor alpha subunit antibody
      • Oncostatin-M receptor subunit alpha antibody
      see all

    References (2)

    Publishing research using ab34315? Please let us know so that we can cite the reference in this datasheet.

    ab34315 has been referenced in 2 publications.

    • Lamertz L  et al. Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130. Cytokine N/A:N/A (2018). PubMed: 29789201
    • Wijdenes J  et al. Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Eur J Immunol 25:3474-81 (1995). PubMed: 8566040

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