Key features and details
- Mouse monoclonal [B-S12] to CD130 (gp130)
- Suitable for: WB, IP, Flow Cyt
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-CD130 (gp130) antibody [B-S12]
See all CD130 (gp130) primary antibodies
DescriptionMouse monoclonal [B-S12] to CD130 (gp130)
Tested applicationsSuitable for: WB, IP, Flow Cytmore details
Species reactivityReacts with: Human
Full length native protein (purified) corresponding to CD130 (gp130).
- Purchase matching WB positive control:Recombinant Human CD130 (gp130) protein
- Eahy 926 cell line.
This product was changed from ascites to tissue culture supernatant on 19th June 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferConstituent: PBS
Concentration information loading...
PurityTissue culture supernatant
Primary antibody notesInduces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation.
Our Abpromise guarantee covers the use of ab27359 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 130 kDa.|
|IP||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionSignal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
Tissue specificityFound in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
modificationsPhosphorylation of Ser-782 down-regulates cell surface expression.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
- CD130 antibody
- CD130 antigen antibody
- CDw130 antibody
ab27359 has been referenced in 1 publication.
- Fourcin M et al. gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses. J Biol Chem 271:11756-60 (1996). ELISA, Functional Studies . PubMed: 8662709