Key features and details
- Rabbit polyclonal to CD161
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-CD161 antibody
See all CD161 primary antibodies
DescriptionRabbit polyclonal to CD161
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Fusion protein within Human CD161 (internal sequence). The exact sequence is proprietary. Fusion protein corresponding to a region derived from internal residues of human CD161. The identity of the protein fusion partner is GST.
Database link: Q12918
- Mouse kidney and human fetal liver tissue lysate. Human thyroid cancer tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197979 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/300 - 1/2000. Predicted molecular weight: 25 kDa.|
|IHC-P||1/50 - 1/200.|
FunctionPlays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Tissue specificityExpressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Sequence similaritiesContains 1 C-type lectin domain.
modificationsN-glycosylated. Contains sialic acid residues.
- Information by UniProt
- C-type lectin domain family 5 member B antibody
- CD161 antibody
- CLEC5B antibody
All lanes : Anti-CD161 antibody (ab197979) at 1/300 dilution
Lane 1 : Mouse kidney lysate
Lane 2 : Human fetal liver tissue lysate
Lysates/proteins at 40 µg per lane.
Predicted band size: 25 kDa
Exposure time: 1 minute
Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue sections labeling CD161 with ab197979 at a 1/50 dilution.
ab197979 has been referenced in 1 publication.
- McGuinness D et al. A molecular signature for delayed graft function. Aging Cell 17:e12825 (2018). PubMed: 30094915