Anti-CD19 antibody [LT19], prediluted (Phycoerythrin) (ab18229)

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Overview

  • Product name

    Anti-CD19 antibody [LT19], prediluted (Phycoerythrin)
    See all CD19 primary antibodies

  • Description

    Mouse monoclonal [LT19] to CD19, prediluted (Phycoerythrin)

  • Host species

    Mouse

  • Conjugation

    Phycoerythrin. Ex: 488nm, Em: 575nm

  • Tested applications

    Suitable for: Flow Cytmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Human B lymphoblast cell line Daudi.

Properties

Applications

Our Abpromise guarantee covers the use of ab18229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

20 µl for a 100 µl sample is recommended.

 

 

 

ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

Target

  • Function

    Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

  • Involvement in disease

    Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

  • Sequence similarities

    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

  • Post-translational
    modifications

    Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • Antibody deficiency due to defect in CD19 antibody
      • Antibody deficiency due to defect in CD19, included antibody
      • AW495831 antibody
      • B lymphocyte antigen CD19 antibody
      • B lymphocyte surface antigen B4 antibody
      • B-lymphocyte antigen CD19 antibody
      • B-lymphocyte surface antigen B4 antibody
      • B4 antibody
      • CD19 antibody
      • CD19 antigen antibody
      • CD19 molecule antibody
      • Cd19 protein antibody
      • CD19_HUMAN antibody
      • CVID3 antibody
      • Differentiation antigen CD19 antibody
      • Leu 12 antibody
      • Leu-12 antibody
      • Leu12 antibody
      • MGC109570 antibody
      • MGC12802 antibody
      • T-cell surface antigen Leu-12 antibody
      see all

    Images

    • Flow Cytometry - Anti-CD19 antibody [LT19], prediluted (Phycoerythrin) (ab18229)
      Flow Cytometry - Anti-CD19 antibody [LT19], prediluted (Phycoerythrin) (ab18229)
      Surface staining of human peripheral blood cells with anti-human CD19 (LT19) PE.�

    References

    This product has been referenced in:

    • te Vruchte D  et al. Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker. J Clin Invest 124:1320-8 (2014). Flow Cyt ; Human . Read more (PubMed: 24487591) »
    See 1 Publication for this product

    Publishing research using ab18229? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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    Flow Cytometry abreview for Anti-CD19 antibody [LT19] (Phycoerythrin), prediluted

     Good
    Abreviews
    Application
    Flow Cytometry
    Sample
    Human Cell (B cells)
    Specification
    B cells
    Permeabilization
    No
    Read More

    Abcam user community

    Verified customer

    Submitted Dec 04 2006

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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